Family-based association testing of glutamate transporter genes in autism

Suma Jacob, Camille W. Brune, Judith A. Badner, Katherine Ernstrom, Eric Courchesne, Catherine Lord, Bennett L. Leventhal, Edwin H. Cook, Soo Jeong Kim

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Glutamate transporters are critical for signaling and excitotoxicity because they regulate extracellular glutamate in the synapse. Four glutamate transporter genes, SLC1A1, SLC1A2, SLC1A3, and SLC1A6, are positional and functional candidates for autism. Studies have implicated SLC1A1 in obsessive-compulsive disorder (Arnold et al., 2006) and autism spectrum disorder (ASD) (Brune et al., 2008). Upregulation of SLC1A2 and SLC1A3 has been reported in brains of individuals with autism (Purcell et al., 2001). SLC1A2 is under the highest linkage peak in the Autism Genome Project scan (Szatmari et al., 2007). Both SLC1A3 and SLC1A6 are most abundantly expressed in cerebellum (Bridges and Esslinger, 2005) where structural and functional deficits occur in autism. On the basis of these lines of evidence, we hypothesized that variations in these four glutamate transporter genes confer risk for autism susceptibility.

Original languageEnglish (US)
Pages (from-to)212-213
Number of pages2
JournalPsychiatric Genetics
Volume21
Issue number4
DOIs
StatePublished - Aug 2011

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