TY - JOUR
T1 - Familial Benign Chronic Pemphigus
T2 - Surgical Treatment and Pathogenesis
AU - Berger, Richard S.
AU - Lynch, Peter J.
N1 - Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.
PY - 1971/10
Y1 - 1971/10
N2 - A patient with recalcitrant familial benign chronic pemphigus was treated with split-thickness grafts to the groin. Postoperative fever and immobilization led to sweating and maceration of the skin, which in turn was followed by widespread clinical disease. This occurrence suggested that in this genodermatosis the susceptible skin is not limited to the neck, axillae, and groin but that hyperhidrosis and subsequent maceration account for this distribution. After surgery, the patient improved but continued to develop occasional cutaneous lesions in the grafted sites following exercise or trauma. We believe that the decreased number of functioning sweat glands (and subsequent decrease in sweating) produced by grafting favorably altered the intertriginous environment and accounted for his clinical improvement.
AB - A patient with recalcitrant familial benign chronic pemphigus was treated with split-thickness grafts to the groin. Postoperative fever and immobilization led to sweating and maceration of the skin, which in turn was followed by widespread clinical disease. This occurrence suggested that in this genodermatosis the susceptible skin is not limited to the neck, axillae, and groin but that hyperhidrosis and subsequent maceration account for this distribution. After surgery, the patient improved but continued to develop occasional cutaneous lesions in the grafted sites following exercise or trauma. We believe that the decreased number of functioning sweat glands (and subsequent decrease in sweating) produced by grafting favorably altered the intertriginous environment and accounted for his clinical improvement.
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U2 - 10.1001/archderm.1971.04000220038007
DO - 10.1001/archderm.1971.04000220038007
M3 - Article
C2 - 4939904
AN - SCOPUS:0015131546
SN - 0003-987X
VL - 104
SP - 380
EP - 384
JO - Archives of Dermatology
JF - Archives of Dermatology
IS - 4
ER -