Familial aggregation of V̇O(2max) response to exercise training: Results from the HERITAGE family study

Claude Bouchard, Ping An, Treva Rice, James S. Skinner, Jack H. Wilmore, Jacques Gagnon, Louis Pérusse, Arthur S. Leon, D. C. Rao

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Abstract

The aim of this study was to test the hypothesis that individual differences in the response of maximal O2 uptake (V̇O(2max)) to a standardized training program are characterized by familial aggregation. A total of 481 sedentary adult Caucasians from 98 two-generation families was exercise trained for 20 wk and was tested for V̇O(2max) on a cycle ergometer twice before and twice after the training program. The mean increase in V̇O(2max) reached ~400 ml/min, but there was considerable heterogeneity in responsiveness, with some individuals experiencing little or no gain, whereas others gained >1.0 l/min. An ANOVA revealed that there was 2.5 times more variance between families than within families in the V̇O(2max) response variance. With the use of a model-fitting procedure, the most parsimonious models yielded a maximal heritability estimate of 47% for the V̇O(2max) response, which was adjusted for age and sex with a maternal transmission of 28% in one of the models. We conclude that the trainability of V̇O(2max) is highly familial and includes a significant genetic component.

Original languageEnglish (US)
Pages (from-to)1003-1008
Number of pages6
JournalJournal of applied physiology
Volume87
Issue number3
DOIs
StatePublished - Sep 1999

Keywords

  • Family lines
  • Heritability
  • Individuality
  • Trainability

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