There is an increasing recognition of patients presenting with cryptococcal meningitis despite having a negative CSF cryptococcal antigen (CrAg). In this report, we describe three cases of patients with advanced immunosuppression who presented to hospital with “false negative” CSF cryptococcal antigen, two of whom had a positive fungal culture. We describe the challenge of CSF-CrAg negative cryptococcal meningitis and explore ways to overcome this challenge using newer diagnostic techniques.
Bibliographical noteFunding Information:
The cases described were in the context of research studies supported by the United States United States Fogarty International Center ( K01TW010268 , R25TW009345 ), National Institute of Neurological Disorders and Stroke ( R01NS086312 ), National Institute of Allergy and Infectious Diseases ( T32AI055433 ), United Kingdom Medical Research Council / Wellcome Trust / Department for International Development ( MRC MR/M007413/1 ) and Grand Challenges Canada ( S4-0296-01 ).
- Cryptococcal meningitis
- Lateral flow assay
- Prozone effect
PubMed: MeSH publication types
- Journal Article