“False negative” CSF cryptococcal antigen with clinical meningitis: Case reports and review of literature

Morris K. Rutakingirwa, Tadeo K. Kiiza, Joshua Rhein

Research output: Contribution to journalArticlepeer-review

Abstract

There is an increasing recognition of patients presenting with cryptococcal meningitis despite having a negative CSF cryptococcal antigen (CrAg). In this report, we describe three cases of patients with advanced immunosuppression who presented to hospital with “false negative” CSF cryptococcal antigen, two of whom had a positive fungal culture. We describe the challenge of CSF-CrAg negative cryptococcal meningitis and explore ways to overcome this challenge using newer diagnostic techniques.

Original languageEnglish (US)
Pages (from-to)29-31
Number of pages3
JournalMedical Mycology Case Reports
Volume29
DOIs
StatePublished - Sep 2020

Bibliographical note

Funding Information:
The cases described were in the context of research studies supported by the United States United States Fogarty International Center ( K01TW010268 , R25TW009345 ), National Institute of Neurological Disorders and Stroke ( R01NS086312 ), National Institute of Allergy and Infectious Diseases ( T32AI055433 ), United Kingdom Medical Research Council / Wellcome Trust / Department for International Development ( MRC MR/M007413/1 ) and Grand Challenges Canada ( S4-0296-01 ).

Keywords

  • Cryptococcal meningitis
  • Cryptococcosis
  • HIV
  • Lateral flow assay
  • Prozone effect

PubMed: MeSH publication types

  • Journal Article

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