Failure of vasopressin and oxytocin to antagonize acute morphine antinociception or facilitate narcotic tolerance development

William K. Schmidt; John W. Holaday; Horace H. Loh; E. Leong Way

doi:10.1016/0024-3205(78)90264-3

Failure of vasopressin and oxytocin to antagonize acute morphine antinociception or facilitate narcotic tolerance development

William K. Schmidt, John W. Holaday, Horace H. Loh, E. Leong Way

Pharmacology

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29 Scopus citations

Abstract

The effects of vasopressin and oxytocin on acute morphine antinociception and on tolerance development were examined in mice and rats. The studies failed to demonstrate any alteration of chronic morphine effects using two separate models of tolerance development in the mouse. Adrenalectomy enhanced the antinociceptive, hyperthermic, and cataleptic effects of acute morphine treatment, but vasopressin was without additional effect in either adrenalectomized or sham-control rats. Furthermore, neither vasopressin nor oxytocin pretreatment altered brain concentrations of acutely injected morphine. It is concluded that the role of vasopressin and oxytocin as endogenous mediators of opiate analgesia or tolerance/dependence is minimal at best.

Original language	English (US)
Pages (from-to)	151-158
Number of pages	8
Journal	Life Sciences
Volume	23
Issue number	2
DOIs	https://doi.org/10.1016/0024-3205(78)90264-3
State	Published - Jul 10 1978

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Other pituitary peptides, including corticotropia (ACTH) and beta-melanocyte stimulating hormone (¢-MSH) have been reported to antagonize acute Supported in part by DA-00006 and DA-00037 and Walter Reed Army Institute of Research .

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title = "Failure of vasopressin and oxytocin to antagonize acute morphine antinociception or facilitate narcotic tolerance development",

abstract = "The effects of vasopressin and oxytocin on acute morphine antinociception and on tolerance development were examined in mice and rats. The studies failed to demonstrate any alteration of chronic morphine effects using two separate models of tolerance development in the mouse. Adrenalectomy enhanced the antinociceptive, hyperthermic, and cataleptic effects of acute morphine treatment, but vasopressin was without additional effect in either adrenalectomized or sham-control rats. Furthermore, neither vasopressin nor oxytocin pretreatment altered brain concentrations of acutely injected morphine. It is concluded that the role of vasopressin and oxytocin as endogenous mediators of opiate analgesia or tolerance/dependence is minimal at best.",

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note = "Funding Information: Other pituitary peptides, including corticotropia (ACTH) and beta-melanocyte stimulating hormone (¢-MSH) have been reported to antagonize acute Supported in part by DA-00006 and DA-00037 and Walter Reed Army Institute of Research .",

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AU - Schmidt, William K.

AU - Holaday, John W.

AU - Loh, Horace H.

AU - Leong Way, E.

N1 - Funding Information: Other pituitary peptides, including corticotropia (ACTH) and beta-melanocyte stimulating hormone (¢-MSH) have been reported to antagonize acute Supported in part by DA-00006 and DA-00037 and Walter Reed Army Institute of Research .

PY - 1978/7/10

Y1 - 1978/7/10

N2 - The effects of vasopressin and oxytocin on acute morphine antinociception and on tolerance development were examined in mice and rats. The studies failed to demonstrate any alteration of chronic morphine effects using two separate models of tolerance development in the mouse. Adrenalectomy enhanced the antinociceptive, hyperthermic, and cataleptic effects of acute morphine treatment, but vasopressin was without additional effect in either adrenalectomized or sham-control rats. Furthermore, neither vasopressin nor oxytocin pretreatment altered brain concentrations of acutely injected morphine. It is concluded that the role of vasopressin and oxytocin as endogenous mediators of opiate analgesia or tolerance/dependence is minimal at best.

AB - The effects of vasopressin and oxytocin on acute morphine antinociception and on tolerance development were examined in mice and rats. The studies failed to demonstrate any alteration of chronic morphine effects using two separate models of tolerance development in the mouse. Adrenalectomy enhanced the antinociceptive, hyperthermic, and cataleptic effects of acute morphine treatment, but vasopressin was without additional effect in either adrenalectomized or sham-control rats. Furthermore, neither vasopressin nor oxytocin pretreatment altered brain concentrations of acutely injected morphine. It is concluded that the role of vasopressin and oxytocin as endogenous mediators of opiate analgesia or tolerance/dependence is minimal at best.

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Failure of vasopressin and oxytocin to antagonize acute morphine antinociception or facilitate narcotic tolerance development

Abstract

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