Failure of vasopressin and oxytocin to antagonize acute morphine antinociception or facilitate narcotic tolerance development

William K. Schmidt, John W. Holaday, Horace H. Loh, E. Leong Way

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29 Scopus citations

Abstract

The effects of vasopressin and oxytocin on acute morphine antinociception and on tolerance development were examined in mice and rats. The studies failed to demonstrate any alteration of chronic morphine effects using two separate models of tolerance development in the mouse. Adrenalectomy enhanced the antinociceptive, hyperthermic, and cataleptic effects of acute morphine treatment, but vasopressin was without additional effect in either adrenalectomized or sham-control rats. Furthermore, neither vasopressin nor oxytocin pretreatment altered brain concentrations of acutely injected morphine. It is concluded that the role of vasopressin and oxytocin as endogenous mediators of opiate analgesia or tolerance/dependence is minimal at best.

Original languageEnglish (US)
Pages (from-to)151-158
Number of pages8
JournalLife Sciences
Volume23
Issue number2
DOIs
StatePublished - Jul 10 1978

Bibliographical note

Funding Information:
Other pituitary peptides, including corticotropia (ACTH) and beta-melanocyte stimulating hormone (¢-MSH) have been reported to antagonize acute Supported in part by DA-00006 and DA-00037 and Walter Reed Army Institute of Research .

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