Failure of Vaccination with Haemophilus influenzae Vaccine

Ronald Pritikin, Robert S. Daum, Michael T. Osterholm, Dan M. Granoff

Research output: Contribution to journalLetterpeer-review

4 Scopus citations


To the Editor: The article by Granoff et al. (Dec. 18 issue)1 raises several points of concern. Although the extent of the network of physicians reporting to the investigators is uncertain, the accepted incidence of Haemophilus influenzae disease in the age bracket of 24 to 48 months is 1:2000.2 With a “vaccine failure” rate of 10 percent, the incidence among those vaccinated becomes 1:20,000. Forty-three cases in the 24- to 48-month age group at immunization would require a cohort of almost 1 million children, or about one seventh of all the children in the country in that age bracket. If…

Original languageEnglish (US)
Pages (from-to)115
Number of pages1
JournalNew England Journal of Medicine
Issue number2
StatePublished - Jul 9 1987


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