Failure of ascorbic acid to inhibit growth of transplantable and dimethylbenzanthracene induced rat mammary tumors

Yusuf J Abul-Hajj, M. Kelliher

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

The effect of ascorbic acid on the growth of 7,12-dimethylbenzanthracene (DMBA)-induced mammary tumor and on growth of R3230AC and MT/W9-B transplantable rat mammary tumors was investigated. High doses of ascorbic acid averaging about 540 mg/day/rat administered orally in drinking water had no effect on the growth of both R3230A and MT/W9a-B transplantable mammary tumors. Furthermore, vitamin C was unable to postpone tumor induction, reduce tumor incidence or prolong survival time of rats treated with DMBA.

Original languageEnglish (US)
Pages (from-to)67-73
Number of pages7
JournalCancer Letters
Volume17
Issue number1
DOIs
StatePublished - Oct 1982

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