Factors associated with vascular stiffness: Cross-sectional analysis from the chronic renal insufficiency standards implementation study

Helen Eddington, Smeeta Sinha, Elizabeth Li, Janet Hegarty, Jeanette Ting, Beverley Lane, Constantina Chrysochou, Rob Foley, Donal O'Donoghue, Philip A. Kalra, Rachel Middleton

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Background: Vascular stiffness is associated with increased cardiovascular risk. This study aimed to identify factors associated with vascular stiffness in a cohort of chronic kidney disease (CKD) patients. Methods: The Chronic Renal Insufficiency Standards Implementation Study is a prospective epidemiological study of CKD patients not on dialysis, who are managed in a clinic setting. Phenotypic parameters were collected annually, and vascular stiffness was assessed using augmentation index (AI). Cross-sectional analysis was performed across quintiles of AI to evaluate factors associated with vascular stiffness. Results: Mean patient age was 66.1 ± 14.1 years and estimated glomerular filtration rate (eGFR) was 31.2 ± 5.7 ml/min. Corrected calcium was 2.26 ± 0.2 SD mmol/l, phosphate 1.2 ± 0.4 SD mmol/l and intact parathyroid hormone 94 ± 96 SD pg/ml; 18.3% of patients had cardiovascular disease. Increased age and systolic blood pressure were associated with increased AI (all p < 0.001). No statistical association was present between AI and eGFR, intact parathyroid hormone, phosphate or protein excretion. Conclusion: This study identified blood pressure as a potentially modifiable risk factor associated with AI, whereas eGFR was not associated with increased AI in a population of CKD stage 3-5 patients. Further knowledge of factors which influence progression of vascular stiffness will be important in risk quantification and management.

Original languageEnglish (US)
Pages (from-to)c190-c198
JournalNephron - Clinical Practice
Volume112
Issue number3
DOIs
StatePublished - Jun 2009

Keywords

  • Augmentation index
  • Chronic kidney disease
  • Glomerular filtration rate
  • Pulse wave velocity
  • Vascular stiffness

Fingerprint

Dive into the research topics of 'Factors associated with vascular stiffness: Cross-sectional analysis from the chronic renal insufficiency standards implementation study'. Together they form a unique fingerprint.

Cite this