Factors associated with real-time RT-PCR cycle threshold values among medically attended influenza episodes

Sarah Spencer; Jessie Chung; Mark Thompson; Pedro A. Piedra; Alan Jewell; Vasanthi Avadhanula; Minghua Mei; Michael L. Jackson; Jennifer Meece; Maria Sundaram; Edward A. Belongia; Rachel Cross; Emileigh Johnson; Arlene Bullotta; Charles Rinaldo; Manjusha Gaglani; Kempapura Murthy; Lydia Clipper; Lashondra Berman; Brendan Flannery

doi:10.1002/jmv.24373

Factors associated with real-time RT-PCR cycle threshold values among medically attended influenza episodes

Sarah Spencer
, Jessie Chung
, Mark Thompson
, Pedro A. Piedra
, Alan Jewell
, Vasanthi Avadhanula
, Minghua Mei
, Michael L. Jackson
, Jennifer Meece
, Maria Sundaram
, Edward A. Belongia
, Rachel Cross
, Emileigh Johnson
, Arlene Bullotta
, Charles Rinaldo
, Manjusha Gaglani
, Kempapura Murthy
, Lydia Clipper
, Lashondra Berman
, Brendan Flannery

Epidemiology & Community Health

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

We evaluated the cycle threshold (CT) values of 1,160 influenza A positive and 806 influenza B positive specimens from two seasons of the US Flu VE Network to identify factors associated with CT values. Low CT values (high genomic load) were associated with shorter intervals between illness onset and specimen collection, young age (ages 3-8 years old), and self-rated illness severity for both influenza A and B. Low CT values were also associated with reported fever/feverishness and age ≥65 years for influenza A.

Original language	English (US)
Pages (from-to)	719-723
Number of pages	5
Journal	Journal of Medical Virology
Volume	88
Issue number	4
DOIs	https://doi.org/10.1002/jmv.24373
State	Published - Apr 1 2016

Bibliographical note

Publisher Copyright:
© 2016 Wiley Periodicals, Inc.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cycle threshold value
Influenza
RT-PCR

Publisher link

10.1002/jmv.24373

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Spencer, S., Chung, J., Thompson, M., Piedra, P. A., Jewell, A., Avadhanula, V., Mei, M., Jackson, M. L., Meece, J., Sundaram, M., Belongia, E. A., Cross, R., Johnson, E., Bullotta, A., Rinaldo, C., Gaglani, M., Murthy, K., Clipper, L., Berman, L., & Flannery, B. (2016). Factors associated with real-time RT-PCR cycle threshold values among medically attended influenza episodes. Journal of Medical Virology, 88(4), 719-723. https://doi.org/10.1002/jmv.24373

Spencer, S, Chung, J, Thompson, M, Piedra, PA, Jewell, A, Avadhanula, V, Mei, M, Jackson, ML, Meece, J, Sundaram, M, Belongia, EA, Cross, R, Johnson, E, Bullotta, A, Rinaldo, C, Gaglani, M, Murthy, K, Clipper, L, Berman, L & Flannery, B 2016, 'Factors associated with real-time RT-PCR cycle threshold values among medically attended influenza episodes', Journal of Medical Virology, vol. 88, no. 4, pp. 719-723. https://doi.org/10.1002/jmv.24373

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abstract = "We evaluated the cycle threshold (CT) values of 1,160 influenza A positive and 806 influenza B positive specimens from two seasons of the US Flu VE Network to identify factors associated with CT values. Low CT values (high genomic load) were associated with shorter intervals between illness onset and specimen collection, young age (ages 3-8 years old), and self-rated illness severity for both influenza A and B. Low CT values were also associated with reported fever/feverishness and age ≥65 years for influenza A.",

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AU - Avadhanula, Vasanthi

AU - Mei, Minghua

AU - Jackson, Michael L.

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AU - Sundaram, Maria

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AU - Cross, Rachel

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AU - Bullotta, Arlene

AU - Rinaldo, Charles

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AU - Murthy, Kempapura

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AU - Berman, Lashondra

AU - Flannery, Brendan

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Factors associated with real-time RT-PCR cycle threshold values among medically attended influenza episodes

Abstract

Bibliographical note

UN SDGs

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