Factors associated with real-time RT-PCR cycle threshold values among medically attended influenza episodes

Sarah Spencer, Jessie Chung, Mark Thompson, Pedro A. Piedra, Alan Jewell, Vasanthi Avadhanula, Minghua Mei, Michael L. Jackson, Jennifer Meece, Maria Sundaram, Edward A. Belongia, Rachel Cross, Emileigh Johnson, Arlene Bullotta, Charles Rinaldo, Manjusha Gaglani, Kempapura Murthy, Lydia Clipper, Lashondra Berman, Brendan Flannery

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

We evaluated the cycle threshold (CT) values of 1,160 influenza A positive and 806 influenza B positive specimens from two seasons of the US Flu VE Network to identify factors associated with CT values. Low CT values (high genomic load) were associated with shorter intervals between illness onset and specimen collection, young age (ages 3-8 years old), and self-rated illness severity for both influenza A and B. Low CT values were also associated with reported fever/feverishness and age ≥65 years for influenza A.

Original languageEnglish (US)
Pages (from-to)719-723
Number of pages5
JournalJournal of Medical Virology
Volume88
Issue number4
DOIs
StatePublished - Apr 1 2016
Externally publishedYes

Keywords

  • Cycle threshold value
  • Influenza
  • RT-PCR

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