Factors associated with osteocalcin in men with spinal cord injury: findings from the FRASCI study

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STUDY DESIGN: Cross-sectional study.

OBJECTIVE: To assess the association between clinical and demographic factors, bisphosphonate use, and circulating total osteocalcin levels in men with chronic spinal cord injury.

SETTING: Veteran Affairs Medical Center.

METHODS: As part of an epidemiological study assessing SCI-related health conditions, 214 men with chronic spinal cord injury underwent a DXA scan and provided a blood sample and information regarding SCI, medication use, and fracture history. General linear models were used to assess clinical/demographic factors of osteocalcin, and if significant, were included in multivariate model.

RESULTS: We found that total osteocalcin levels increased 1.0 ng/ml for every kilogram increase in lean mass (p = 0.05) and increased 4.53 ng/ml for every ng/ml increase in C-telopeptide level (p < 0.0001). Osteocalcin levels were greater in people reporting no alcohol consumption compared with drinkers (15.49 ng/ml versus 18.58 ng/ml, p < 0.0002), lower in diabetics compared with nondiabetics (15.23 ng/ml versus 18.92 ng/ml, p = 0.0001), and lower in bisphosphonate users compared with nonusers (15.50 ng/ml versus 18.58 ng/ml, p < 0.03). The association between age and osteocalcin was not significant (p = 0.06). This model explained 58% of the variation in ln osteocalcin levels (model p < 0.0001, r 2  = 0.58).

CONCLUSIONS: Total osteocalcin levels vary based on health habits, body composition, comorbid illnesses, and bisphosphonate use in men with chronic spinal cord injury.

Original languageEnglish (US)
Pages (from-to)1014-1022
Number of pages9
JournalSpinal Cord
Issue number12
StatePublished - Dec 1 2019

Bibliographical note

Funding Information:
Acknowledgements This study received support from The National Institute of Arthritis and Musculoskeletal and Skin Diseases [1R01AR059270-01] and [R01AR064793-01A1].

Publisher Copyright:
© 2019, The Author(s), under exclusive licence to International Spinal Cord Society.

PubMed: MeSH publication types

  • Journal Article


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