Factors associated with osteocalcin in men with spinal cord injury: findings from the FRASCI study

Ricardo A. Battaglino; Nguyen M Nguyen; Megan Summers; Leslie R. Morse

doi:10.1038/s41393-019-0327-8

Factors associated with osteocalcin in men with spinal cord injury: findings from the FRASCI study

Ricardo A. Battaglino, Nguyen M Nguyen, Megan Summers, Leslie R. Morse

Physical Medicine & Rehabilitation

Research output: Contribution to journal › Article › peer-review

Abstract

STUDY DESIGN: Cross-sectional study.

OBJECTIVE: To assess the association between clinical and demographic factors, bisphosphonate use, and circulating total osteocalcin levels in men with chronic spinal cord injury.

SETTING: Veteran Affairs Medical Center.

METHODS: As part of an epidemiological study assessing SCI-related health conditions, 214 men with chronic spinal cord injury underwent a DXA scan and provided a blood sample and information regarding SCI, medication use, and fracture history. General linear models were used to assess clinical/demographic factors of osteocalcin, and if significant, were included in multivariate model.

RESULTS: We found that total osteocalcin levels increased 1.0 ng/ml for every kilogram increase in lean mass (p = 0.05) and increased 4.53 ng/ml for every ng/ml increase in C-telopeptide level (p < 0.0001). Osteocalcin levels were greater in people reporting no alcohol consumption compared with drinkers (15.49 ng/ml versus 18.58 ng/ml, p < 0.0002), lower in diabetics compared with nondiabetics (15.23 ng/ml versus 18.92 ng/ml, p = 0.0001), and lower in bisphosphonate users compared with nonusers (15.50 ng/ml versus 18.58 ng/ml, p < 0.03). The association between age and osteocalcin was not significant (p = 0.06). This model explained 58% of the variation in ln osteocalcin levels (model p < 0.0001, r 2 = 0.58).

CONCLUSIONS: Total osteocalcin levels vary based on health habits, body composition, comorbid illnesses, and bisphosphonate use in men with chronic spinal cord injury.

Original language	English (US)
Pages (from-to)	1014-1022
Number of pages	9
Journal	Spinal Cord
Volume	57
Issue number	12
DOIs	https://doi.org/10.1038/s41393-019-0327-8
State	Published - Dec 1 2019

Bibliographical note

Funding Information:
Acknowledgements This study received support from The National Institute of Arthritis and Musculoskeletal and Skin Diseases [1R01AR059270-01] and [R01AR064793-01A1].

Publisher Copyright:
© 2019, The Author(s), under exclusive licence to International Spinal Cord Society.

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Journal Article

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title = "Factors associated with osteocalcin in men with spinal cord injury: findings from the FRASCI study",

abstract = "STUDY DESIGN: Cross-sectional study.OBJECTIVE: To assess the association between clinical and demographic factors, bisphosphonate use, and circulating total osteocalcin levels in men with chronic spinal cord injury.SETTING: Veteran Affairs Medical Center.METHODS: As part of an epidemiological study assessing SCI-related health conditions, 214 men with chronic spinal cord injury underwent a DXA scan and provided a blood sample and information regarding SCI, medication use, and fracture history. General linear models were used to assess clinical/demographic factors of osteocalcin, and if significant, were included in multivariate model.RESULTS: We found that total osteocalcin levels increased 1.0 ng/ml for every kilogram increase in lean mass (p = 0.05) and increased 4.53 ng/ml for every ng/ml increase in C-telopeptide level (p < 0.0001). Osteocalcin levels were greater in people reporting no alcohol consumption compared with drinkers (15.49 ng/ml versus 18.58 ng/ml, p < 0.0002), lower in diabetics compared with nondiabetics (15.23 ng/ml versus 18.92 ng/ml, p = 0.0001), and lower in bisphosphonate users compared with nonusers (15.50 ng/ml versus 18.58 ng/ml, p < 0.03). The association between age and osteocalcin was not significant (p = 0.06). This model explained 58% of the variation in ln osteocalcin levels (model p < 0.0001, r 2 = 0.58). CONCLUSIONS: Total osteocalcin levels vary based on health habits, body composition, comorbid illnesses, and bisphosphonate use in men with chronic spinal cord injury.",

author = "Battaglino, {Ricardo A.} and Nguyen, {Nguyen M} and Megan Summers and Morse, {Leslie R.}",

note = "Funding Information: Acknowledgements This study received support from The National Institute of Arthritis and Musculoskeletal and Skin Diseases [1R01AR059270-01] and [R01AR064793-01A1]. Publisher Copyright: {\textcopyright} 2019, The Author(s), under exclusive licence to International Spinal Cord Society.",

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doi = "10.1038/s41393-019-0327-8",

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T1 - Factors associated with osteocalcin in men with spinal cord injury

T2 - findings from the FRASCI study

AU - Battaglino, Ricardo A.

AU - Nguyen, Nguyen M

AU - Summers, Megan

AU - Morse, Leslie R.

N1 - Funding Information: Acknowledgements This study received support from The National Institute of Arthritis and Musculoskeletal and Skin Diseases [1R01AR059270-01] and [R01AR064793-01A1]. Publisher Copyright: © 2019, The Author(s), under exclusive licence to International Spinal Cord Society.

PY - 2019/12/1

Y1 - 2019/12/1

N2 - STUDY DESIGN: Cross-sectional study.OBJECTIVE: To assess the association between clinical and demographic factors, bisphosphonate use, and circulating total osteocalcin levels in men with chronic spinal cord injury.SETTING: Veteran Affairs Medical Center.METHODS: As part of an epidemiological study assessing SCI-related health conditions, 214 men with chronic spinal cord injury underwent a DXA scan and provided a blood sample and information regarding SCI, medication use, and fracture history. General linear models were used to assess clinical/demographic factors of osteocalcin, and if significant, were included in multivariate model.RESULTS: We found that total osteocalcin levels increased 1.0 ng/ml for every kilogram increase in lean mass (p = 0.05) and increased 4.53 ng/ml for every ng/ml increase in C-telopeptide level (p < 0.0001). Osteocalcin levels were greater in people reporting no alcohol consumption compared with drinkers (15.49 ng/ml versus 18.58 ng/ml, p < 0.0002), lower in diabetics compared with nondiabetics (15.23 ng/ml versus 18.92 ng/ml, p = 0.0001), and lower in bisphosphonate users compared with nonusers (15.50 ng/ml versus 18.58 ng/ml, p < 0.03). The association between age and osteocalcin was not significant (p = 0.06). This model explained 58% of the variation in ln osteocalcin levels (model p < 0.0001, r 2 = 0.58). CONCLUSIONS: Total osteocalcin levels vary based on health habits, body composition, comorbid illnesses, and bisphosphonate use in men with chronic spinal cord injury.

AB - STUDY DESIGN: Cross-sectional study.OBJECTIVE: To assess the association between clinical and demographic factors, bisphosphonate use, and circulating total osteocalcin levels in men with chronic spinal cord injury.SETTING: Veteran Affairs Medical Center.METHODS: As part of an epidemiological study assessing SCI-related health conditions, 214 men with chronic spinal cord injury underwent a DXA scan and provided a blood sample and information regarding SCI, medication use, and fracture history. General linear models were used to assess clinical/demographic factors of osteocalcin, and if significant, were included in multivariate model.RESULTS: We found that total osteocalcin levels increased 1.0 ng/ml for every kilogram increase in lean mass (p = 0.05) and increased 4.53 ng/ml for every ng/ml increase in C-telopeptide level (p < 0.0001). Osteocalcin levels were greater in people reporting no alcohol consumption compared with drinkers (15.49 ng/ml versus 18.58 ng/ml, p < 0.0002), lower in diabetics compared with nondiabetics (15.23 ng/ml versus 18.92 ng/ml, p = 0.0001), and lower in bisphosphonate users compared with nonusers (15.50 ng/ml versus 18.58 ng/ml, p < 0.03). The association between age and osteocalcin was not significant (p = 0.06). This model explained 58% of the variation in ln osteocalcin levels (model p < 0.0001, r 2 = 0.58). CONCLUSIONS: Total osteocalcin levels vary based on health habits, body composition, comorbid illnesses, and bisphosphonate use in men with chronic spinal cord injury.

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DO - 10.1038/s41393-019-0327-8

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SN - 1362-4393

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SP - 1014

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JO - Spinal Cord

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Factors associated with osteocalcin in men with spinal cord injury: findings from the FRASCI study

Abstract

Bibliographical note

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UN SDGs

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