TY - JOUR
T1 - Factors associated with non-adherence to antiretroviral therapy in the SUN study
AU - Kyser, Melanie
AU - Buchacz, Kate
AU - Bush, Timothy J.
AU - Conley, Lois J.
AU - Hammer, John
AU - Henry, Keith
AU - Kojic, Erna M.
AU - Milam, Joel
AU - Overton, E. Turner
AU - Wood, Kathy C.
AU - Brooks, John T.
PY - 2011/5
Y1 - 2011/5
N2 - Background:. Adherence of 95% or greater to highly active combination antiretroviral therapy is generally considered necessary to achieve optimal virologic suppression in HIV-infected patients. Understanding factors associated with poor adherence is essential to improve patient compliance, maximize virologic suppression, and reduce morbidity and mortality. Methods:. We evaluated baseline data from 528 patients taking antiretrovirals, enrolled from March 2004 to June 2006, in a multicenter, longitudinal, prospective cohort study (the SUN study). Using multiple logistic regression, we examined independent risk factors for non-adherence, defined as reporting having missed one or more antiretroviral doses in the past three days on the baseline questionnaire. Results:. Of 528 participants (22% female, 28% black, median age 41 years, and median CD4 cell count 486 cells/mm3), 85 (16%) were non-adherent. In the final parsimonious multivariate model, factors independently associated with non-adherence included black race (adjusted odds ratio (aOR): 2. 08, 95% confidence interval (CI): 1.20-3.60 vs. white race), being unemployed and looking for work (aOR: 2.03, 95% CI: 1.14-3.61 vs. all other employment categories), having been diagnosed with HIV ≥ 5 years ago (aOR: 1. 95, 95% CI: 1.18-3.24 vs. being HIV-diagnosed <5 years ago), drinking three or more drinks per day (aOR: 1.73, 95% CI: 1.02-2.91 vs. drinking <3 drinks per day), and having not engaged in any aerobic exercise in the last 30 days (aOR: 2. 13, 95% CI: 1.25-3.57). Conclusion:. Although the above factors may not be causally related to non-adherence, they might serve as proxies for identifying HIV-infected patients at greatest risk for non-adherence who may benefit from additional adherence support.
AB - Background:. Adherence of 95% or greater to highly active combination antiretroviral therapy is generally considered necessary to achieve optimal virologic suppression in HIV-infected patients. Understanding factors associated with poor adherence is essential to improve patient compliance, maximize virologic suppression, and reduce morbidity and mortality. Methods:. We evaluated baseline data from 528 patients taking antiretrovirals, enrolled from March 2004 to June 2006, in a multicenter, longitudinal, prospective cohort study (the SUN study). Using multiple logistic regression, we examined independent risk factors for non-adherence, defined as reporting having missed one or more antiretroviral doses in the past three days on the baseline questionnaire. Results:. Of 528 participants (22% female, 28% black, median age 41 years, and median CD4 cell count 486 cells/mm3), 85 (16%) were non-adherent. In the final parsimonious multivariate model, factors independently associated with non-adherence included black race (adjusted odds ratio (aOR): 2. 08, 95% confidence interval (CI): 1.20-3.60 vs. white race), being unemployed and looking for work (aOR: 2.03, 95% CI: 1.14-3.61 vs. all other employment categories), having been diagnosed with HIV ≥ 5 years ago (aOR: 1. 95, 95% CI: 1.18-3.24 vs. being HIV-diagnosed <5 years ago), drinking three or more drinks per day (aOR: 1.73, 95% CI: 1.02-2.91 vs. drinking <3 drinks per day), and having not engaged in any aerobic exercise in the last 30 days (aOR: 2. 13, 95% CI: 1.25-3.57). Conclusion:. Although the above factors may not be causally related to non-adherence, they might serve as proxies for identifying HIV-infected patients at greatest risk for non-adherence who may benefit from additional adherence support.
KW - Adherence
KW - Cart
KW - HAART
KW - Risk factors
UR - http://www.scopus.com/inward/record.url?scp=79956032772&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79956032772&partnerID=8YFLogxK
U2 - 10.1080/09540121.2010.525603
DO - 10.1080/09540121.2010.525603
M3 - Article
C2 - 21293992
AN - SCOPUS:79956032772
SN - 0954-0121
VL - 23
SP - 601
EP - 611
JO - AIDS Care - Psychological and Socio-Medical Aspects of AIDS/HIV
JF - AIDS Care - Psychological and Socio-Medical Aspects of AIDS/HIV
IS - 5
ER -