Factor VII, cholesterol, and triglycerides: The CARDIA Study

David Green, Mary Ann Chamberlain, Karen J. Ruth, Aaron R. Folsom, Kiang Liu

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23 Scopus citations


Cross-sectional studies have shown that factor VII coagulant activity (VII(c)) is positively associated with plasma total cholesterol (TC), LDL cholesterol, and triglycerides (TG) as well as body mass index (BMI) and diastolic blood pressure. To determine whether changes in VII(c) parallel changes in coronary risk factors over a period of 2 years, we examined data from 1514 participants in the Coronary Artery Risk Development in Young Adults Study (CARDIA), an ongoing investigation of lifestyles and evolution of cardiovascular risk factors. Subjects were 23 to 35 years old at the year 5 examination. Cross-sectional analyses at these examinations showed that VII(c) was positively correlated (P<.001) with TC and TG in all race/sex groups except for TC in black women at the year 5 examination. Changes in VII(c) over the 2-year period were correlated positively with changes in TC in all except black men and TG in all groups; the association of VII(c) change with change in TC and TG was reduced only slightly with adjustment for age and BMI at year 5 and 2-year change in BMI. To determine whether the higher levels of VII(c) in subjects with higher lipid values were due to activation of the factor or to an increase in the concentration of the factor VII clotting protein, we measured factor VII antigen (VII(ag)) in a randomly selected subsample of 223 subjects at the year 7 examination. In all sex/race groups, VII(ag) correlated with VII(c) (r=.69 to 0.81). After adjustment for sex and race, the partial correlation coefficient between TG and VII(c) was .28 (P=.0001); between TG and VII(ag), .35 (P=.0001); between TC and VII(c), .39 (P=.0001); and between TC and VII(ag), 0.43 (P=.0001). No associations were observed between lipid levels and the ratio of VII(c) to VII(ag). We conclude that the raised VII(c) with higher lipid levels occurs in blacks as well as whites, in men and women, persists over time, and represents a true increase in the plasma concentration of this clotting factor.

Original languageEnglish (US)
Pages (from-to)51-55
Number of pages5
JournalArteriosclerosis, thrombosis, and vascular biology
Issue number1
StatePublished - 1997


  • factor VII
  • lipids
  • thrombosis risk factors


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