Factor V Leiden: How great is the risk of venous thromboembolism?

Khaldoon Shaheen, M. Chadi Alraies, Abdul Hamid Alraiyes, Richard Christie

Research output: Contribution to journalReview articlepeer-review

23 Scopus citations


The factor V Leiden mutation, the most common inherited cause of thrombophilia, causes a mild hypercoagulable state. We describe a 29-year-old man, heterozygous for factor V Leiden, who developed extensive pulmonary emboli with concomitant bilateral deep venous thrombosis, likely provoked by prolonged immobility during a car trip. We then review the diagnosis, therapy, screening, and prognosis of venous thromboembolism related to factor V Leiden.

Original languageEnglish (US)
Pages (from-to)265-272
Number of pages8
JournalCleveland Clinic journal of medicine
Issue number4
StatePublished - Apr 2012


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