Facilitation of muricide in rats by cholinergic stimulation of the lateral hypothalamus

Byron C. Yoburn; Murray Glusman; Michael Potegal; Ludmila Skaredoff

doi:10.1016/0091-3057(81)90017-4

Facilitation of muricide in rats by cholinergic stimulation of the lateral hypothalamus

Byron C. Yoburn, Murray Glusman, Michael Potegal, Ludmila Skaredoff

Occupational Therapy

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5 Scopus citations

Abstract

The effect of cholinergic stimulation of the lateral hypothalamus on muricide in rats was evaluated in two experiments. In Experiment 1, injections of the cholinergic agonist carbachol (5.0-20.0 μg) were found to facilitate muricide in rats that spontaneously killed mice. In Experiment 2, rats were induced to kill mice by food deprivation and then stimulated with carbachol (2.5-5.0 μg). Facilitation of muricide was found to be coincident with increased scores on a handling difficulty (irritability) scale for the majority of rats. These results suggest that facilitation of muricade by cholinergic stimulation of lateral hypothalamic areas may be related to increases in irritable aggression.

Original language	English (US)
Pages (from-to)	747-753
Number of pages	7
Journal	Pharmacology, Biochemistry and Behavior
Volume	15
Issue number	5
DOIs	https://doi.org/10.1016/0091-3057(81)90017-4
State	Published - Nov 1981

Keywords

Aggression
Carbachol
Cholinergic stimulation
Handling
Interspecific aggression
Irritability
Lateral hypothalamus
Muricide
Rats

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title = "Facilitation of muricide in rats by cholinergic stimulation of the lateral hypothalamus",

abstract = "The effect of cholinergic stimulation of the lateral hypothalamus on muricide in rats was evaluated in two experiments. In Experiment 1, injections of the cholinergic agonist carbachol (5.0-20.0 μg) were found to facilitate muricide in rats that spontaneously killed mice. In Experiment 2, rats were induced to kill mice by food deprivation and then stimulated with carbachol (2.5-5.0 μg). Facilitation of muricide was found to be coincident with increased scores on a handling difficulty (irritability) scale for the majority of rats. These results suggest that facilitation of muricade by cholinergic stimulation of lateral hypothalamic areas may be related to increases in irritable aggression.",

keywords = "Aggression, Carbachol, Cholinergic stimulation, Handling, Interspecific aggression, Irritability, Lateral hypothalamus, Muricide, Rats",

author = "Yoburn, {Byron C.} and Murray Glusman and Michael Potegal and Ludmila Skaredoff",

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AU - Yoburn, Byron C.

AU - Glusman, Murray

AU - Potegal, Michael

AU - Skaredoff, Ludmila

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