Facile preparation and reactivity of polymer-supported N-(2-lodyl-phenyl)- acylamide, an Efficient Oxidizing System

Uladzimir Ladziata, Jeff Willging, Viktor Zhdankin

Research output: Contribution to journalArticlepeer-review

46 Scopus citations

Abstract

(Chemical Equation Presented) A simple three-step preparation of polymer-supported N-(2-iodyl-phenyl)-acylamide (NIPA resin) starting from 2-iodoaniline is described. The resin was obtained with good loading levels (0.7-0.8 mmol g-1) and has been successfully used for efficient oxidation of a diverse collection of alcohols. Thus, treating alcohols with 1.0 equiv of the resin in 1,2-dichloroethane under reflux for 30-60 min allowed rapid and in most cases complete conversion to the corresponding carbonyl compound.

Original languageEnglish (US)
Pages (from-to)167-170
Number of pages4
JournalOrganic Letters
Volume8
Issue number1
DOIs
StatePublished - Jan 5 2006

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