Facially amphiphilic polyionene biocidal polymers derived from lithocholic acid

Mitra S. Ganewatta, Md Anisur Rahman, Louis Mercado, Tinom Shokfai, Alan W. Decho, Theresa M. Reineke, Chuanbing Tang

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Bacterial infections have become a global issue that requires urgent attention, particularly regarding to emergence of multidrug resistant bacteria. We developed quaternary amine-containing antimicrobial poly(bile acid)s that contain a hydrophobic core of lithocholic acid in the main-chain. Interestingly, by choosing appropriate monomers, these cationic polymers can form core-shell micelles. These polymers exhibited biocidal activity against both Gram-positive and Gram-negative bacterial species. It is demonstrated that the micelles can deliver hydrophobic antibiotics that functionally have dual antimicrobial activities. Cytotoxicity assays against HeLa cells showed dosage-dependent toxicity for polymers with longer linkers.

Original languageEnglish (US)
Pages (from-to)186-193
Number of pages8
JournalBioactive Materials
Volume3
Issue number2
DOIs
StatePublished - Jun 2018

Keywords

  • Antimicrobial polymers
  • Bile acid
  • Facial amphiphilicity
  • Lithocholic acid
  • Polyionene
  • Quaternary ammonium

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