TY - JOUR
T1 - F 2-isoprostanes and adiposity in older adults
AU - Kanaya, Alka M.
AU - Wassel, Christina L.
AU - Stoddard, Pamela J.
AU - Harris, Tamara B.
AU - Cummings, Steven R.
AU - Kritchevsky, Stephen B.
AU - Goodpaster, Bret H.
AU - Green, Christie
AU - Satterfield, Suzanne
AU - Gross, Myron D.
PY - 2011/4
Y1 - 2011/4
N2 - We examined whether a systemic marker of oxidative stress, F 2-isoprostanes (F 2-IPs), was associated with total and regional adiposity, adipocytokines, and change in adiposity. Using data from 726 participants enrolled in the Health, Aging, and Body Composition (Health ABC) study, F 2-IPs and adipocytokines were measured from baseline plasma samples. Total adiposity was measured by whole-body dual-energy X-ray absorptiometry and regional adiposity by abdominal and thigh computed tomography scans at baseline and 5-year follow-up. ANOVA models were estimated to examine associations between F 2-IP tertiles and baseline adiposity and changes in body composition. Median F 2-IPs was 54.3pg/ml; women had significantly higher levels than men (61.5vs. 48.9pg/ml, P 0.001). F 2-IPs were associated with higher levels of adiponectin, leptin, and tumor necrosis factor-α (TNF-α). Positive associations were found between F 2-IPs and all measures of total and regional adiposity among women. In linear regression models, adipocytokines mediated associations among women. Over 5 years of follow-up, women in the highest vs. lowest F 2-IP tertile exhibited significant loss of weight (lowest tertile: 1.1kg, highest tertile: 2.7kg, P 0.05). In conclusion, F 2-IPs were associated with measures of total and regional adiposity in women alone and these associations were partially explained by adipocytokines. F 2-IPs predicted loss of total adiposity over time among women.
AB - We examined whether a systemic marker of oxidative stress, F 2-isoprostanes (F 2-IPs), was associated with total and regional adiposity, adipocytokines, and change in adiposity. Using data from 726 participants enrolled in the Health, Aging, and Body Composition (Health ABC) study, F 2-IPs and adipocytokines were measured from baseline plasma samples. Total adiposity was measured by whole-body dual-energy X-ray absorptiometry and regional adiposity by abdominal and thigh computed tomography scans at baseline and 5-year follow-up. ANOVA models were estimated to examine associations between F 2-IP tertiles and baseline adiposity and changes in body composition. Median F 2-IPs was 54.3pg/ml; women had significantly higher levels than men (61.5vs. 48.9pg/ml, P 0.001). F 2-IPs were associated with higher levels of adiponectin, leptin, and tumor necrosis factor-α (TNF-α). Positive associations were found between F 2-IPs and all measures of total and regional adiposity among women. In linear regression models, adipocytokines mediated associations among women. Over 5 years of follow-up, women in the highest vs. lowest F 2-IP tertile exhibited significant loss of weight (lowest tertile: 1.1kg, highest tertile: 2.7kg, P 0.05). In conclusion, F 2-IPs were associated with measures of total and regional adiposity in women alone and these associations were partially explained by adipocytokines. F 2-IPs predicted loss of total adiposity over time among women.
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U2 - 10.1038/oby.2010.243
DO - 10.1038/oby.2010.243
M3 - Article
C2 - 20948516
AN - SCOPUS:79953187567
SN - 1930-7381
VL - 19
SP - 861
EP - 867
JO - Obesity
JF - Obesity
IS - 4
ER -