Alterations in serum glucose concentration have been shown to modulate the responsiveness of animals to opiates. In the present study we found that genetically obese diabetic mice (C57 BL/Ks-db+/db+) were about 80 times more sensitive to the suppressive effect of naloxone on food intake than their heterozygote littermate controls. Streptozotocin-induced diabetic mice were 1000 times more sensitive to naloxone's inhibitory effect on feeding than were their controls. These results suggest that high serum glucose levels, rather than obesity, induce extreme sensitivity to naloxone-induced suppression of food intake.
Bibliographical noteFunding Information:
We thank Julie Kneip and Sheryl Hess for their excellent technical assistance, and JoAnn Tallman for her secretarial aid. This work was supported by the American Diabetes Association, the American Diabetes Association of Minnesota, USPHS grant AM 25879 and the Veterans Administration. Dr. Handwerger was a recipient of a Veterans Administration Cfinical Investigator award.
- Food intake