Extravascular penetration of tobramycin and netilmicin in a subcutaneous Visking chamber model in rabbits

T. A. Larson, D. N. Gerding, L. R. Peterson

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Netilmicin and tobramycin penetration in a rabbit Visking chamber model was studied after administration of multiple intramuscular doses of 2 mg of either drug per kg every 4 h in a double-crossover design. The mean serum half-life, mean peak concentration in serum, and mean area under the plasma concentration curve were similar. The mean peak concentration in the chamber and mean area under the plasma concentration curve were likewise not significantly different.

Original languageEnglish (US)
Pages (from-to)594-596
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume24
Issue number4
DOIs
StatePublished - Jan 1 1983

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