Extraordinary metabolic stability of peptides containing α-aminoxy acids

Fei Chen; Bin Ma; Zong Chang Yang; Ge Lin; Dan Yang

doi:10.1007/s00726-011-1095-8

Extraordinary metabolic stability of peptides containing α-aminoxy acids

Fei Chen, Bin Ma, Zong Chang Yang, Ge Lin, Dan Yang

Carcinogenesis and Chemoprevention

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

The metabolic stability of peptides containing a mixed sequence of α-aminoxy acids and α-amino acids is significantly improved compared to peptides composed of only natural α-amino acids. The introduction of an α-aminoxy acid into peptide chain dramatically improves the stability of the amide bonds immediately before and after it. These peptides containing α-aminoxy acids represent excellent structural scaffold for the design of metabolically stable and biologically active peptides.

Original language	English (US)
Pages (from-to)	499-503
Number of pages	5
Journal	Amino Acids
Volume	43
Issue number	1
DOIs	https://doi.org/10.1007/s00726-011-1095-8
State	Published - Jul 1 2012

Keywords

Aminoxy acid
Metabolism
Peptides
Stability

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AU - Ma, Bin

AU - Yang, Zong Chang

AU - Lin, Ge

AU - Yang, Dan

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Y1 - 2012/7/1

N2 - The metabolic stability of peptides containing a mixed sequence of α-aminoxy acids and α-amino acids is significantly improved compared to peptides composed of only natural α-amino acids. The introduction of an α-aminoxy acid into peptide chain dramatically improves the stability of the amide bonds immediately before and after it. These peptides containing α-aminoxy acids represent excellent structural scaffold for the design of metabolically stable and biologically active peptides.

AB - The metabolic stability of peptides containing a mixed sequence of α-aminoxy acids and α-amino acids is significantly improved compared to peptides composed of only natural α-amino acids. The introduction of an α-aminoxy acid into peptide chain dramatically improves the stability of the amide bonds immediately before and after it. These peptides containing α-aminoxy acids represent excellent structural scaffold for the design of metabolically stable and biologically active peptides.

KW - Aminoxy acid

KW - Metabolism

KW - Peptides

KW - Stability

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