Extracting drug-drug interaction articles from MEDLINE to improve the content of drug databases.

Stephany Duda, Constantin Aliferis, Randolph Miller, Alexander Statnikov, Kevin Johnson

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

Drug-drug interaction systems exhibit low signal-to-noise ratios because of the amount of clinically insignificant or inaccurate information they contain. MEDLINE represents a respected source of peer-reviewed biomedical citations that potentially might serve as a valuable source of drug-drug interaction information, if relevant articles could be pinpointed effectively and efficiently. We evaluated the classification capability of Support Vector Machines as a method for locating articles about drug interactions. We used a corpus of "positive" and"negative" drug interaction citations to generate datasets composed of MeSH terms, CUI-tagged title and abstract text, and stemmed text words. The study showed that automated classification techniques have the potential to perform at least as well as PubMed in identifying drug-drug interaction articles.

Original languageEnglish (US)
Pages (from-to)216-220
Number of pages5
JournalAMIA ... Annual Symposium proceedings / AMIA Symposium. AMIA Symposium
StatePublished - 2005

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