Extracorporeal membrane oxygenation in children receiving haematopoietic cell transplantation and immune effector cell therapy: an international and multidisciplinary consensus statement

Matteo Di Nardo; Ali H Ahmad; Pietro Merli; Matthew S Zinter; Leslie E Lehman; Courtney M Rowan; Marie E Steiner; Sangeeta Hingorani; Joseph R Angelo; Hisham Abdel-azim; Sajad J Khazal; Basirat Shoberu; Jennifer Mcarthur; Rajinder Bajwa; Saad Ghafoor; Samir H Shah; Hitesh Sandhu; Karen Moody; Brandon D Brown; Maria E Mireles; Diana Steppan; Taylor Olson; Lakshmi Raman; Brian Bridges; Christine N Duncan; Sung Won Choi; Rita Swinford; Matt Paden; James D Fortenberry; Giles Peek; Pierre Tissieres; Daniele De Luca; Franco Locatelli; Selim Corbacioglu; Martin Kneyber; Alessio Franceschini; Simon Nadel; Matthias Kumpf; Alessandra Loreti; Roelie Wösten-van Asperen; Orsola Gawronski; Joe Brierley; Graeme Maclaren; Kris M Mahadeo

doi:10.1016/s2352-4642(21)00336-9

Extracorporeal membrane oxygenation in children receiving haematopoietic cell transplantation and immune effector cell therapy: an international and multidisciplinary consensus statement

Matteo Di Nardo, Ali H Ahmad, Pietro Merli, Matthew S Zinter, Leslie E Lehman, Courtney M Rowan, Marie E Steiner, Sangeeta Hingorani, Joseph R Angelo, Hisham Abdel-azim, Sajad J Khazal, Basirat Shoberu, Jennifer Mcarthur, Rajinder Bajwa, Saad Ghafoor, Samir H Shah, Hitesh Sandhu, Karen Moody, Brandon D Brown, Maria E MirelesDiana Steppan, Taylor Olson, Lakshmi Raman, Brian Bridges, Christine N Duncan, Sung Won Choi, Rita Swinford, Matt Paden, James D Fortenberry, Giles Peek, Pierre Tissieres, Daniele De Luca, Franco Locatelli, Selim Corbacioglu, Martin Kneyber, Alessio Franceschini, Simon Nadel, Matthias Kumpf, Alessandra Loreti, Roelie Wösten-van Asperen, Orsola Gawronski, Joe Brierley, Graeme Maclaren, Kris M Mahadeo

Research output: Contribution to journal › Review article › peer-review

18 Scopus citations

Abstract

Use of extracorporeal membrane oxygenation (ECMO) in children receiving haematopoietic cell transplantation (HCT) and immune effector cell therapy is controversial and evidence-based guidelines have not been established. Remarkable advancements in HCT and immune effector cell therapies have changed expectations around reversibility of organ dysfunction and survival for affected patients. Herein, members of the Extracorporeal Life Support Organization (ELSO), Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network (HCT and cancer immunotherapy subgroup), the Pediatric Diseases Working Party of the European Society for Blood and Marrow Transplantation (EBMT), the supportive care committee of the Pediatric Transplantation and Cellular Therapy Consortium (PTCTC), and the Pediatric Intensive Care Oncology Kids in Europe Research (POKER) group of the European Society of Pediatric and Neonatal Intensive Care (ESPNIC) provide consensus recommendations on the use of ECMO in children receiving HCT and immune effector cell therapy. These are the first international, multidisciplinary consensus-based recommendations on the use of ECMO in this patient population. This Review provides a clinical decision support tool for paediatric haematologists, oncologists, and critical care physicians during the difficult decision-making process of ECMO candidacy and management. These recommendations can represent a base for future research studies focused on ECMO selection criteria and bedside management.

Original language	English (US)
Pages (from-to)	116-128
Number of pages	13
Journal	The Lancet Child and Adolescent Health
Volume	6
Issue number	2
DOIs	https://doi.org/10.1016/s2352-4642(21)00336-9
State	Published - Feb 1 2022

Bibliographical note

Funding Information:
We acknowledge the memberships of AHA, MSZ, LEL, CMR, MES, SH, JRA, HA-A, BS, JMcA, RB, SG, SHS, HS, BDB, CND, and KMM to the Pediatric Acute Lung Injury and Sepsis Investigators Network; HA-A, RB, SWC, and KMM to Pediatric Transplantation and Cellular Therapy Consortium; MDN, PT, DDL, MKn, SN, RW-VA, OG, and JB to the Pediatric Intensive Care Oncology Kids in Europe Research group of the European Society of Pediatric and Neonatal Intensive Care; MDN, SG, SHS, HS, DS, TO, LR, BB, MP, JDF, GP, and GM to the Extracorporeal Life Support Organization; and PM, FL, SC, AF, and MKu to the Pediatric Diseases Working Party of the European Society for Blood and Marrow Transplantation. There are no relevant funding sources to disclose.

Publisher Copyright:
© 2022 Elsevier Ltd

PubMed: MeSH publication types

Journal Article
Review

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/s2352-4642(21)00336-9

https://linkinghub.elsevier.com/retrieve/pii/S2352464221003369

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Di Nardo, M., Ahmad, A. H., Merli, P., Zinter, M. S., Lehman, L. E., Rowan, C. M., Steiner, M. E., Hingorani, S., Angelo, J. R., Abdel-azim, H., Khazal, S. J., Shoberu, B., Mcarthur, J., Bajwa, R., Ghafoor, S., Shah, S. H., Sandhu, H., Moody, K., Brown, B. D., ... Mahadeo, K. M. (2022). Extracorporeal membrane oxygenation in children receiving haematopoietic cell transplantation and immune effector cell therapy: an international and multidisciplinary consensus statement. The Lancet Child and Adolescent Health, 6(2), 116-128. https://doi.org/10.1016/s2352-4642(21)00336-9

Extracorporeal membrane oxygenation in children receiving haematopoietic cell transplantation and immune effector cell therapy: an international and multidisciplinary consensus statement. / Di Nardo, Matteo; Ahmad, Ali H; Merli, Pietro et al.
In: The Lancet Child and Adolescent Health, Vol. 6, No. 2, 01.02.2022, p. 116-128.

Research output: Contribution to journal › Review article › peer-review

Di Nardo, M, Ahmad, AH, Merli, P, Zinter, MS, Lehman, LE, Rowan, CM, Steiner, ME, Hingorani, S, Angelo, JR, Abdel-azim, H, Khazal, SJ, Shoberu, B, Mcarthur, J, Bajwa, R, Ghafoor, S, Shah, SH, Sandhu, H, Moody, K, Brown, BD, Mireles, ME, Steppan, D, Olson, T, Raman, L, Bridges, B, Duncan, CN, Choi, SW, Swinford, R, Paden, M, Fortenberry, JD, Peek, G, Tissieres, P, De Luca, D, Locatelli, F, Corbacioglu, S, Kneyber, M, Franceschini, A, Nadel, S, Kumpf, M, Loreti, A, Wösten-van Asperen, R, Gawronski, O, Brierley, J, Maclaren, G & Mahadeo, KM 2022, 'Extracorporeal membrane oxygenation in children receiving haematopoietic cell transplantation and immune effector cell therapy: an international and multidisciplinary consensus statement', The Lancet Child and Adolescent Health, vol. 6, no. 2, pp. 116-128. https://doi.org/10.1016/s2352-4642(21)00336-9

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abstract = "Use of extracorporeal membrane oxygenation (ECMO) in children receiving haematopoietic cell transplantation (HCT) and immune effector cell therapy is controversial and evidence-based guidelines have not been established. Remarkable advancements in HCT and immune effector cell therapies have changed expectations around reversibility of organ dysfunction and survival for affected patients. Herein, members of the Extracorporeal Life Support Organization (ELSO), Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network (HCT and cancer immunotherapy subgroup), the Pediatric Diseases Working Party of the European Society for Blood and Marrow Transplantation (EBMT), the supportive care committee of the Pediatric Transplantation and Cellular Therapy Consortium (PTCTC), and the Pediatric Intensive Care Oncology Kids in Europe Research (POKER) group of the European Society of Pediatric and Neonatal Intensive Care (ESPNIC) provide consensus recommendations on the use of ECMO in children receiving HCT and immune effector cell therapy. These are the first international, multidisciplinary consensus-based recommendations on the use of ECMO in this patient population. This Review provides a clinical decision support tool for paediatric haematologists, oncologists, and critical care physicians during the difficult decision-making process of ECMO candidacy and management. These recommendations can represent a base for future research studies focused on ECMO selection criteria and bedside management.",

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note = "Funding Information: We acknowledge the memberships of AHA, MSZ, LEL, CMR, MES, SH, JRA, HA-A, BS, JMcA, RB, SG, SHS, HS, BDB, CND, and KMM to the Pediatric Acute Lung Injury and Sepsis Investigators Network; HA-A, RB, SWC, and KMM to Pediatric Transplantation and Cellular Therapy Consortium; MDN, PT, DDL, MKn, SN, RW-VA, OG, and JB to the Pediatric Intensive Care Oncology Kids in Europe Research group of the European Society of Pediatric and Neonatal Intensive Care; MDN, SG, SHS, HS, DS, TO, LR, BB, MP, JDF, GP, and GM to the Extracorporeal Life Support Organization; and PM, FL, SC, AF, and MKu to the Pediatric Diseases Working Party of the European Society for Blood and Marrow Transplantation. There are no relevant funding sources to disclose. Publisher Copyright: {\textcopyright} 2022 Elsevier Ltd",

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AU - Lehman, Leslie E

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Extracorporeal membrane oxygenation in children receiving haematopoietic cell transplantation and immune effector cell therapy: an international and multidisciplinary consensus statement

Abstract

Bibliographical note

PubMed: MeSH publication types

UN SDGs

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