Extracorporeal CPR after the INCEPTION trial: No one steps twice into the same river

Tommaso Scquizzato, Demetris Yannopoulos, Jan Bělohlávek, Fabio S. Taccone, Roberto Lorusso, Anna Mara Scandroglio, Giovanni Landoni, Justyna Swol

Research output: Contribution to journalArticlepeer-review


The use of veno-arterial extracorporeal membrane oxygenation as extracorporeal cardiopulmonary resuscitation in patients suffering out-of-hospital cardiac arrest, largely increased in the last decade despite evidence supporting this practice being limited to non-randomized studies. However, between 2020 and 2023, four randomized studies were published comparing extracorporeal cardiopulmonary resuscitation to conventional cardiopulmonary resuscitation with controversial findings that triggered great debates. In this controversy, we discuss merits and pitfalls, and provide a critical interpretation of the available evidence from randomized trials on the use of extracorporeal cardiopulmonary resuscitation, with a particular focus on the recent multi-center INCEPTION trial.

Original languageEnglish (US)
Pages (from-to)802-805
Number of pages4
JournalArtificial Organs
Issue number5
StatePublished - May 2023

Bibliographical note

Publisher Copyright:
© 2023 The Authors. Artificial Organs published by International Center for Artificial Organ and Transplantation (ICAOT) and Wiley Periodicals LLC.


  • ECLS
  • ECMO
  • ECPR
  • OHCA
  • extracorporeal cardiopulmonary resuscitation
  • extracorporeal life support
  • extracorporeal membrane oxygenation
  • out-of-hospital cardiac arrest

PubMed: MeSH publication types

  • Journal Article


Dive into the research topics of 'Extracorporeal CPR after the INCEPTION trial: No one steps twice into the same river'. Together they form a unique fingerprint.

Cite this