Extracellular Vesicles in Molecular Diagnostics: An Overview with a Focus on CNS Diseases

B. R. Hirshman; R. T. Kras; J. C. Akers; B. S. Carter; C. C. Chen

doi:10.1016/bs.acc.2016.05.005

Extracellular Vesicles in Molecular Diagnostics: An Overview with a Focus on CNS Diseases

B. R. Hirshman
, R. T. Kras
, J. C. Akers
, B. S. Carter
, C. C. Chen

Neurosurgery

Research output: Chapter in Book/Report/Conference proceeding › Chapter

17 Scopus citations

Abstract

All known cells continuously release nanoscale lipid membrane-enclosed packets. These packets, termed extracellular vesicles (EVs), bear the signature of their cells of origin. These vesicles can be detected in just about every type of biofluid tested, including blood, urine, and cerebrospinal fluid. The majority comes from normal cells, but disease cells also release them. There is a great interest in collecting and analyzing EVs in biofluids as diagnostics for a wide spectrum of central nervous system diseases. Here, we will review the state of central nervous system EV research in terms of molecular diagnostics and biomarkers.

Original language	English (US)
Title of host publication	Advances in Clinical Chemistry
Editors	Gregory S. Makowski, Gregory S. Makowski
Publisher	Academic Press Inc.
Pages	37-53
Number of pages	17
ISBN (Print)	9780128046876
DOIs	https://doi.org/10.1016/bs.acc.2016.05.005
State	Published - 2016

Publication series

Name	Advances in Clinical Chemistry
Volume	76
ISSN (Print)	0065-2423

Bibliographical note

Publisher Copyright:
© 2016 Elsevier Inc.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Brain cancer
Exosome
Extracellular vesicle
Neurodegenerative diseases

Publisher link

10.1016/bs.acc.2016.05.005

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Extracellular Vesicles in Molecular Diagnostics: An Overview with a Focus on CNS Diseases. / Hirshman, B. R.; Kras, R. T.; Akers, J. C. et al.
Advances in Clinical Chemistry. ed. / Gregory S. Makowski; Gregory S. Makowski. Academic Press Inc., 2016. p. 37-53 (Advances in Clinical Chemistry; Vol. 76).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

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abstract = "All known cells continuously release nanoscale lipid membrane-enclosed packets. These packets, termed extracellular vesicles (EVs), bear the signature of their cells of origin. These vesicles can be detected in just about every type of biofluid tested, including blood, urine, and cerebrospinal fluid. The majority comes from normal cells, but disease cells also release them. There is a great interest in collecting and analyzing EVs in biofluids as diagnostics for a wide spectrum of central nervous system diseases. Here, we will review the state of central nervous system EV research in terms of molecular diagnostics and biomarkers.",

keywords = "Brain cancer, Exosome, Extracellular vesicle, Neurodegenerative diseases",

author = "Hirshman, \{B. R.\} and Kras, \{R. T.\} and Akers, \{J. C.\} and Carter, \{B. S.\} and Chen, \{C. C.\}",

note = "Publisher Copyright: {\textcopyright} 2016 Elsevier Inc.",

year = "2016",

doi = "10.1016/bs.acc.2016.05.005",

language = "English (US)",

isbn = "9780128046876",

series = "Advances in Clinical Chemistry",

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AU - Kras, R. T.

AU - Akers, J. C.

AU - Carter, B. S.

AU - Chen, C. C.

PY - 2016

Y1 - 2016

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AB - All known cells continuously release nanoscale lipid membrane-enclosed packets. These packets, termed extracellular vesicles (EVs), bear the signature of their cells of origin. These vesicles can be detected in just about every type of biofluid tested, including blood, urine, and cerebrospinal fluid. The majority comes from normal cells, but disease cells also release them. There is a great interest in collecting and analyzing EVs in biofluids as diagnostics for a wide spectrum of central nervous system diseases. Here, we will review the state of central nervous system EV research in terms of molecular diagnostics and biomarkers.

KW - Brain cancer

KW - Exosome

KW - Extracellular vesicle

KW - Neurodegenerative diseases

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UR - https://www.scopus.com/pages/publications/84999836293#tab=citedBy

U2 - 10.1016/bs.acc.2016.05.005

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M3 - Chapter

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AN - SCOPUS:84999836293

SN - 9780128046876

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BT - Advances in Clinical Chemistry

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ER -

Extracellular Vesicles in Molecular Diagnostics: An Overview with a Focus on CNS Diseases

Abstract

Publication series

Bibliographical note

UN SDGs

Keywords

Publisher link

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