Extracellular Vesicles in Molecular Diagnostics: An Overview with a Focus on CNS Diseases

B. R. Hirshman, R. T. Kras, J. C. Akers, B. S. Carter, C. C. Chen

Research output: Chapter in Book/Report/Conference proceedingChapter

10 Scopus citations


All known cells continuously release nanoscale lipid membrane-enclosed packets. These packets, termed extracellular vesicles (EVs), bear the signature of their cells of origin. These vesicles can be detected in just about every type of biofluid tested, including blood, urine, and cerebrospinal fluid. The majority comes from normal cells, but disease cells also release them. There is a great interest in collecting and analyzing EVs in biofluids as diagnostics for a wide spectrum of central nervous system diseases. Here, we will review the state of central nervous system EV research in terms of molecular diagnostics and biomarkers.

Original languageEnglish (US)
Title of host publicationAdvances in Clinical Chemistry
EditorsGregory S. Makowski, Gregory S. Makowski
PublisherAcademic Press Inc.
Number of pages17
ISBN (Print)9780128046876
StatePublished - 2016

Publication series

NameAdvances in Clinical Chemistry
ISSN (Print)0065-2423

Bibliographical note

Funding Information:
The work is supported by NIH UH2 TR000931-0, NIH PO1 2P30CA023100-28 (B.S.C. and C.C.C.). C.C.C. is supported by the Doris Duke Charitable Foundation Clinical Scientist Development Award, Sontag Foundation Distinguished Scientist Award, Burroughs Wellcome Fund Career Awards for Medical Scientists, the Kimmel Scholar Award, a Grant from Accelerated Brain Cancer Cure, and the William Guy Forbeck Research Foundation.

Publisher Copyright:
© 2016 Elsevier Inc.


  • Brain cancer
  • Exosome
  • Extracellular vesicle
  • Neurodegenerative diseases


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