Extracellular vesicles as novel delivery tools for cancer treatment

Erdogan Pekcan Erkan, Okay Saydam

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Extracellular vesicles (EVs) are different types of membrane-derived vesicles that originate from the endosomal pathway or the plasma membrane. These vesicles are used as “carriers” in intercellular communication, and are responsible for the transfer of biological cargo (lipids, proteins, RNA species, and DNA) between different cells. Despite the shortcomings in our knowledge of EV biology, attempts to employ EVs as natural delivery tools for therapeutic purposes have been partly successful in different settings. In this review, we highlight this unique potential of EVs, and discuss previous examples and future scenarios.

Original languageEnglish (US)
Pages (from-to)34-42
Number of pages9
JournalCurrent Cancer Drug Targets
Volume16
Issue number1
DOIs
StatePublished - Jan 1 2016
Externally publishedYes

Keywords

  • Cancer
  • Delivery
  • Extracellular vesicles
  • Therapeutics

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