Extracellular Vesicles as a Platform for Glioma Therapeutic Development

David R. Santiago-DIeppa; David D. Gonda; Vincent J. Cheung; Jeffery A. Steinberg; Bob S. Carter; Clark C. Chen

doi:10.1159/000469689

Extracellular Vesicles as a Platform for Glioma Therapeutic Development

David R. Santiago-DIeppa, David D. Gonda, Vincent J. Cheung, Jeffery A. Steinberg, Bob S. Carter, Clark C. Chen

Neurosurgery

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Normal and pathologic cells secrete extracellular vesicles (EV), which are defined as 30-2,000 nm spherical organelles. It has been found that EV mediate various biological functions including cellular remodeling and export of biomolecules, extracellular communication, immune stimulation and suppression, and modulation of the cellular microenvironment. EV secreted by human glioma cells contain a wealth of tumor-specific proteins and nucleic acids that can be isolated from patients with these neoplasms. Thus, EV contribute to the development of biomarkers, and additionally have certain therapeutic potential for possible use in neuro-oncology and neurosurgery.

Original language	English (US)
Pages (from-to)	172-179
Number of pages	8
Journal	Progress in Neurological Surgery
Volume	32
DOIs	https://doi.org/10.1159/000469689
State	Published - Jan 1 2018

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title = "Extracellular Vesicles as a Platform for Glioma Therapeutic Development",

abstract = "Normal and pathologic cells secrete extracellular vesicles (EV), which are defined as 30-2,000 nm spherical organelles. It has been found that EV mediate various biological functions including cellular remodeling and export of biomolecules, extracellular communication, immune stimulation and suppression, and modulation of the cellular microenvironment. EV secreted by human glioma cells contain a wealth of tumor-specific proteins and nucleic acids that can be isolated from patients with these neoplasms. Thus, EV contribute to the development of biomarkers, and additionally have certain therapeutic potential for possible use in neuro-oncology and neurosurgery.",

author = "Santiago-DIeppa, {David R.} and Gonda, {David D.} and Cheung, {Vincent J.} and Steinberg, {Jeffery A.} and Carter, {Bob S.} and Chen, {Clark C.}",

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AU - Gonda, David D.

AU - Cheung, Vincent J.

AU - Steinberg, Jeffery A.

AU - Carter, Bob S.

AU - Chen, Clark C.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Normal and pathologic cells secrete extracellular vesicles (EV), which are defined as 30-2,000 nm spherical organelles. It has been found that EV mediate various biological functions including cellular remodeling and export of biomolecules, extracellular communication, immune stimulation and suppression, and modulation of the cellular microenvironment. EV secreted by human glioma cells contain a wealth of tumor-specific proteins and nucleic acids that can be isolated from patients with these neoplasms. Thus, EV contribute to the development of biomarkers, and additionally have certain therapeutic potential for possible use in neuro-oncology and neurosurgery.

AB - Normal and pathologic cells secrete extracellular vesicles (EV), which are defined as 30-2,000 nm spherical organelles. It has been found that EV mediate various biological functions including cellular remodeling and export of biomolecules, extracellular communication, immune stimulation and suppression, and modulation of the cellular microenvironment. EV secreted by human glioma cells contain a wealth of tumor-specific proteins and nucleic acids that can be isolated from patients with these neoplasms. Thus, EV contribute to the development of biomarkers, and additionally have certain therapeutic potential for possible use in neuro-oncology and neurosurgery.

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ER -

Extracellular Vesicles as a Platform for Glioma Therapeutic Development

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