Extracellular matrix in lung development, homeostasis and disease

Yong Zhou; Jeffrey C. Horowitz; Alexandra Naba; Namasivayam Ambalavanan; Kamran Atabai; Jenna Balestrini; Peter B. Bitterman; Richard A. Corley; Bi Sen Ding; Adam J. Engler; Kirk C. Hansen; James S. Hagood; Farrah Kheradmand; Qing S. Lin; Enid Neptune; Laura Niklason; Luis A. Ortiz; William C. Parks; Daniel J. Tschumperlin; Eric S. White; Harold A. Chapman; Victor J. Thannickal

doi:10.1016/j.matbio.2018.03.005

Extracellular matrix in lung development, homeostasis and disease

Yong Zhou, Jeffrey C. Horowitz, Alexandra Naba, Namasivayam Ambalavanan, Kamran Atabai, Jenna Balestrini, Peter B. Bitterman, Richard A. Corley, Bi Sen Ding, Adam J. Engler, Kirk C. Hansen, James S. Hagood, Farrah Kheradmand, Qing S. Lin, Enid Neptune, Laura Niklason, Luis A. Ortiz, William C. Parks, Daniel J. Tschumperlin, Eric S. WhiteHarold A. Chapman, Victor J. Thannickal

Pulmonary, Allergy, Critical Care and Sleep Medicine

Research output: Contribution to journal › Review article › peer-review

198 Scopus citations

Abstract

The lung's unique extracellular matrix (ECM), while providing structural support for cells, is critical in the regulation of developmental organogenesis, homeostasis and injury-repair responses. The ECM, via biochemical or biomechanical cues, regulates diverse cell functions, fate and phenotype. The composition and function of lung ECM become markedly deranged in pathological tissue remodeling. ECM-based therapeutics and bioengineering approaches represent promising novel strategies for regeneration/repair of the lung and treatment of chronic lung diseases. In this review, we assess the current state of lung ECM biology, including fundamental advances in ECM composition, dynamics, topography, and biomechanics; the role of the ECM in normal and aberrant lung development, adult lung diseases and autoimmunity; and ECM in the regulation of the stem cell niche. We identify opportunities to advance the field of lung ECM biology and provide a set recommendations for research priorities to advance knowledge that would inform novel approaches to the pathogenesis, diagnosis, and treatment of chronic lung diseases.

Original language	English (US)
Pages (from-to)	77-104
Number of pages	28
Journal	Matrix Biology
Volume	73
DOIs	https://doi.org/10.1016/j.matbio.2018.03.005
State	Published - Nov 2018

Bibliographical note

Funding Information:
We acknowledge the support of the Division of Lung Diseases, National Heart, Lung & Blood Institute which initially organized a workshop on this topic on September 17?18, 2014 in Bethesda, Maryland. All authors of this manuscript participated in this workshop. The authors thank J. Michael Wells, MD, Derek Russell, MD and J. Edwin Blalock, PhD for their contributions to the construction of Fig. 5.

Publisher Copyright:
© 2018 Elsevier B.V.

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https://escholarship.org/uc/item/8xq996h2

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Zhou, Y., Horowitz, J. C., Naba, A., Ambalavanan, N., Atabai, K., Balestrini, J., Bitterman, P. B., Corley, R. A., Ding, B. S., Engler, A. J., Hansen, K. C., Hagood, J. S., Kheradmand, F., Lin, Q. S., Neptune, E., Niklason, L., Ortiz, L. A., Parks, W. C., Tschumperlin, D. J., ... Thannickal, V. J. (2018). Extracellular matrix in lung development, homeostasis and disease. Matrix Biology, 73, 77-104. https://doi.org/10.1016/j.matbio.2018.03.005

Zhou, Y, Horowitz, JC, Naba, A, Ambalavanan, N, Atabai, K, Balestrini, J, Bitterman, PB, Corley, RA, Ding, BS, Engler, AJ, Hansen, KC, Hagood, JS, Kheradmand, F, Lin, QS, Neptune, E, Niklason, L, Ortiz, LA, Parks, WC, Tschumperlin, DJ, White, ES, Chapman, HA & Thannickal, VJ 2018, 'Extracellular matrix in lung development, homeostasis and disease', Matrix Biology, vol. 73, pp. 77-104. https://doi.org/10.1016/j.matbio.2018.03.005

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title = "Extracellular matrix in lung development, homeostasis and disease",

abstract = "The lung's unique extracellular matrix (ECM), while providing structural support for cells, is critical in the regulation of developmental organogenesis, homeostasis and injury-repair responses. The ECM, via biochemical or biomechanical cues, regulates diverse cell functions, fate and phenotype. The composition and function of lung ECM become markedly deranged in pathological tissue remodeling. ECM-based therapeutics and bioengineering approaches represent promising novel strategies for regeneration/repair of the lung and treatment of chronic lung diseases. In this review, we assess the current state of lung ECM biology, including fundamental advances in ECM composition, dynamics, topography, and biomechanics; the role of the ECM in normal and aberrant lung development, adult lung diseases and autoimmunity; and ECM in the regulation of the stem cell niche. We identify opportunities to advance the field of lung ECM biology and provide a set recommendations for research priorities to advance knowledge that would inform novel approaches to the pathogenesis, diagnosis, and treatment of chronic lung diseases.",

author = "Yong Zhou and Horowitz, {Jeffrey C.} and Alexandra Naba and Namasivayam Ambalavanan and Kamran Atabai and Jenna Balestrini and Bitterman, {Peter B.} and Corley, {Richard A.} and Ding, {Bi Sen} and Engler, {Adam J.} and Hansen, {Kirk C.} and Hagood, {James S.} and Farrah Kheradmand and Lin, {Qing S.} and Enid Neptune and Laura Niklason and Ortiz, {Luis A.} and Parks, {William C.} and Tschumperlin, {Daniel J.} and White, {Eric S.} and Chapman, {Harold A.} and Thannickal, {Victor J.}",

note = "Funding Information: We acknowledge the support of the Division of Lung Diseases, National Heart, Lung & Blood Institute which initially organized a workshop on this topic on September 17?18, 2014 in Bethesda, Maryland. All authors of this manuscript participated in this workshop. The authors thank J. Michael Wells, MD, Derek Russell, MD and J. Edwin Blalock, PhD for their contributions to the construction of Fig. 5. Publisher Copyright: {\textcopyright} 2018 Elsevier B.V.",

year = "2018",

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doi = "10.1016/j.matbio.2018.03.005",

language = "English (US)",

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AU - Zhou, Yong

AU - Horowitz, Jeffrey C.

AU - Naba, Alexandra

AU - Ambalavanan, Namasivayam

AU - Atabai, Kamran

AU - Balestrini, Jenna

AU - Bitterman, Peter B.

AU - Corley, Richard A.

AU - Ding, Bi Sen

AU - Engler, Adam J.

AU - Hansen, Kirk C.

AU - Hagood, James S.

AU - Kheradmand, Farrah

AU - Lin, Qing S.

AU - Neptune, Enid

AU - Niklason, Laura

AU - Ortiz, Luis A.

AU - Parks, William C.

AU - Tschumperlin, Daniel J.

AU - White, Eric S.

AU - Chapman, Harold A.

AU - Thannickal, Victor J.

N1 - Funding Information: We acknowledge the support of the Division of Lung Diseases, National Heart, Lung & Blood Institute which initially organized a workshop on this topic on September 17?18, 2014 in Bethesda, Maryland. All authors of this manuscript participated in this workshop. The authors thank J. Michael Wells, MD, Derek Russell, MD and J. Edwin Blalock, PhD for their contributions to the construction of Fig. 5. Publisher Copyright: © 2018 Elsevier B.V.

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N2 - The lung's unique extracellular matrix (ECM), while providing structural support for cells, is critical in the regulation of developmental organogenesis, homeostasis and injury-repair responses. The ECM, via biochemical or biomechanical cues, regulates diverse cell functions, fate and phenotype. The composition and function of lung ECM become markedly deranged in pathological tissue remodeling. ECM-based therapeutics and bioengineering approaches represent promising novel strategies for regeneration/repair of the lung and treatment of chronic lung diseases. In this review, we assess the current state of lung ECM biology, including fundamental advances in ECM composition, dynamics, topography, and biomechanics; the role of the ECM in normal and aberrant lung development, adult lung diseases and autoimmunity; and ECM in the regulation of the stem cell niche. We identify opportunities to advance the field of lung ECM biology and provide a set recommendations for research priorities to advance knowledge that would inform novel approaches to the pathogenesis, diagnosis, and treatment of chronic lung diseases.

AB - The lung's unique extracellular matrix (ECM), while providing structural support for cells, is critical in the regulation of developmental organogenesis, homeostasis and injury-repair responses. The ECM, via biochemical or biomechanical cues, regulates diverse cell functions, fate and phenotype. The composition and function of lung ECM become markedly deranged in pathological tissue remodeling. ECM-based therapeutics and bioengineering approaches represent promising novel strategies for regeneration/repair of the lung and treatment of chronic lung diseases. In this review, we assess the current state of lung ECM biology, including fundamental advances in ECM composition, dynamics, topography, and biomechanics; the role of the ECM in normal and aberrant lung development, adult lung diseases and autoimmunity; and ECM in the regulation of the stem cell niche. We identify opportunities to advance the field of lung ECM biology and provide a set recommendations for research priorities to advance knowledge that would inform novel approaches to the pathogenesis, diagnosis, and treatment of chronic lung diseases.

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Extracellular matrix in lung development, homeostasis and disease

Abstract

Bibliographical note

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