External pallidal stimulation improves parkinsonian motor signs and modulates neuronal activity throughout the basal ganglia thalamic network

Jerrold L Vitek, Jianyu Zhang, Takao Hashimoto, Gary S. Russo, Kenneth Baker

Research output: Contribution to journalArticle

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Abstract

Deep brain stimulation (DBS) of the internal segment of the globus pallidus (GPi) and the subthalamic nucleus (STN) are effective for the treatment of advanced Parkinson's disease (PD). We have shown previously that DBS of the external segment of the globus pallidus (GPe) is associated with improvements in parkinsonian motor signs; however, the mechanism of this effect is not known. In this study, we extend our findings on the effect of STN and GPi DBS on neuronal activity in the basal ganglia thalamic network to include GPe DBS using the 1-methyl-4-phenyl-1.2.3.6-tetrahydropyridine (MPTP) monkey model. Stimulation parameters that improved bradykinesia were associated with changes in the pattern and mean discharge rate of neuronal activity in the GPi, STN, and the pallidal [ventralis lateralis pars oralis (VLo) and ventralis anterior (VA)] and cerebellar [ventralis lateralis posterior pars oralis (VPLo)] receiving areas of the motor thalamus. Population post-stimulation time histograms revealed a complex pattern of stimulation-related inhibition and excitation for the GPi and VA/VLo, with a more consistent pattern of inhibition in STN and excitation in VPLo. Mean discharge rate was reduced in the GPi and STN and increased in the VPLo. Effective GPe DBS also reduced bursting in the STN and GPi. These data support the hypothesis that therapeutic DBS activates output from the stimulated structure and changes the temporal pattern of neuronal activity throughout the basal ganglia thalamic network and provide further support for GPe as a potential therapeutic target for DBS in the treatment of PD.

Original languageEnglish (US)
Pages (from-to)581-586
Number of pages6
JournalExperimental Neurology
Volume233
Issue number1
DOIs
StatePublished - Jan 1 2012

Fingerprint

Globus Pallidus
Deep Brain Stimulation
Subthalamic Nucleus
Basal Ganglia
Parkinson Disease
Ventral Thalamic Nuclei
Hypokinesia
Motor Cortex
Therapeutics
Thalamus
Haplorhini
Population

Keywords

  • Deep brain stimulation
  • Globus pallidus
  • MPTP (1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine)
  • Monkey
  • Parkinsonism

Cite this

External pallidal stimulation improves parkinsonian motor signs and modulates neuronal activity throughout the basal ganglia thalamic network. / Vitek, Jerrold L; Zhang, Jianyu; Hashimoto, Takao; Russo, Gary S.; Baker, Kenneth.

In: Experimental Neurology, Vol. 233, No. 1, 01.01.2012, p. 581-586.

Research output: Contribution to journalArticle

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