External-beam Co-60 radiotherapy for canine nasal tumors: A comparison of survival by treatment protocol

J. H. Yoon, D. A. Feeney, C. R. Jessen, P. A. Walter

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14 Scopus citations


A retrospective analysis of survival times in dogs with intranasal tumors was performed comparing those treated using hypofractionated or full course Co-60 radiotherapy protocols alone or with surgical adjuvant therapy and those receiving no radiation treatment. One hundred thirty-nine dogs presented to the University of Minnesota Veterinary Medical Center for treatment of histologically-confirmed nasal neoplasia between July 1983 and October 2001 met the criteria for review. Statistically analyzed parameters included age at diagnosis, tumor histologic classification, fractionation schedule (number of treatments, and number of treatment days/week) (classified as hypofractionated if 2 or less treatments/week); calculated minimum tumor dose/fraction; calculated total minimum tumor dose (classified as hypofractionated if less than 37 Gy in six or fewer fractions); number of radiotherapy portals, a treatment gap of more than 7 days in a full course (3-5 treatments/week, 3-3.5 week treatment time) radiotherapy protocol, the influence of eye shields on survival following single portal DV fields, the survey radiographic extent of the disease, and the presence or absence of cytoreductive surgery. There was a significant relationship only between protocols using 3 or more treatments/week and at least 37 Gy cumulative minimum tumor dose and survival. However, there was no significant relationship between either total minimum tumor dose or dose/fraction and survival and there were no significant relationships between survival and any of the other variables analyzed including tumor histologic type.

Original languageEnglish (US)
Pages (from-to)140-149
Number of pages10
JournalResearch in veterinary science
Issue number1
StatePublished - Feb 2008

Bibliographical note

Funding Information:
Junghee Yoon was supported by 2001 Overseas Research Grant of LG Yonam Foundation.


  • Dog
  • Nasal
  • Neoplasm
  • Radiotherapy protocol
  • Survival


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