External application of fermented olive flounder (Paralichthys Olivaceus) oil alleviates inflammatory responses in 2,4-dinitrochlorobenzene- induced atopic dermatitis mouse model

Sang Chul Han, Gyeoung Jin Kang, Yeong Jong Ko, Hee Kyoung Kang, Sang Wook Moon, Yong Seok Ann, Eun Sook Yoo

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Allergic skin inflammation such as atopic dermatitis (AD) is characterized by edema and infiltration with various inflammatory cells such as mast cells, basophils, eosinophils and T cells. Thymic stromal lymphopoietin (TSLP) is produced mainly by epidermal keratinocytes, as well as dermal fibroblasts and mast cells in the skin lesions of AD. Omega-3 polyunsaturated fatty acids in fish oil can reduce inflammation in allergic patients. Fermentation has a tremendous capacity to transform chemical structures. The antiinflammatory effects of fish oil have been described in many diseases, but the beneficial effects by which fermented olive flounder oil (FOF) modulates the allergic response is poorlyunderstood. In this study, we produced FOF and tested its ability to suppress the various allergic inflammatory responses. The ability of FOF to modulate the immune system was investigated using a mousemodel of AD. The FOF-treated group showed significantly decreased immunoglobulin E (IgE) and histamine in serum. Also, the increased TSLP expression was significantly inhibited in the FOF group; the FOF-treated group was not appreciably different from the hydrocort cream treatment group. In addition, FOF treatment resulted in a smaller spleen size with reduced the thickness and length compared to the induction group. Splenocytes from mice treated with FOF produced significantly less IFN-γ, IL-4, T-box transcription factor (T-bet) and GATA binding protein 3 (GATA3) expression compared with the induction group. These results suggest that FOF may be effective in treating the allergic symptoms of AD. 5.

Original languageEnglish (US)
Pages (from-to)159-164
Number of pages6
JournalToxicological Research
Volume28
Issue number3
DOIs
StatePublished - 2012
Externally publishedYes

Keywords

  • Atopic dermatitis
  • Fermented olive flounder oil
  • GATA binding protein 3
  • T-box transcription factor
  • Thymic stromal lymphopoietin

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