Extension of life-span with superoxide dismutase/catalase mimetics

S. Melov, J. Ravenscroft, S. Malik, M. S. Gill, D. W. Walker, P. E. Clayton, D. C. Wallace, B. Malfroy, S. R. Doctrow, G. J. Lithgow

Research output: Contribution to journalArticlepeer-review

791 Scopus citations

Abstract

We tested the theory that reactive oxygen species cause aging. We augmented the natural antioxidant systems of Caenorhabditis elegans with small synthetic superoxide dismutase/catalase mimetics. Treatment of wild-type worms increased their mean life-span by a mean of 44 percent, and treatment of prematurely aging worms resulted in normalization of their life-span (a 67 percent increase). It appears that oxidative stress is a major determinant of life-span and that it can be counteracted by pharmacological intervention.

Original languageEnglish (US)
Pages (from-to)1567-1569
Number of pages3
JournalScience
Volume289
Issue number5484
DOIs
StatePublished - Sep 1 2000
Externally publishedYes

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