Extension of life-span with superoxide dismutase/catalase mimetics

S. Melov; J. Ravenscroft; S. Malik; M. S. Gill; D. W. Walker; P. E. Clayton; D. C. Wallace; B. Malfroy; S. R. Doctrow; G. J. Lithgow

doi:10.1126/science.289.5484.1567

Extension of life-span with superoxide dismutase/catalase mimetics

S. Melov, J. Ravenscroft, S. Malik, M. S. Gill, D. W. Walker, P. E. Clayton, D. C. Wallace, B. Malfroy, S. R. Doctrow, G. J. Lithgow

Research output: Contribution to journal › Article › peer-review

774 Scopus citations

Abstract

We tested the theory that reactive oxygen species cause aging. We augmented the natural antioxidant systems of Caenorhabditis elegans with small synthetic superoxide dismutase/catalase mimetics. Treatment of wild-type worms increased their mean life-span by a mean of 44 percent, and treatment of prematurely aging worms resulted in normalization of their life-span (a 67 percent increase). It appears that oxidative stress is a major determinant of life-span and that it can be counteracted by pharmacological intervention.

Original language	English (US)
Pages (from-to)	1567-1569
Number of pages	3
Journal	Science
Volume	289
Issue number	5484
DOIs	https://doi.org/10.1126/science.289.5484.1567
State	Published - Sep 1 2000
Externally published	Yes

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10.1126/science.289.5484.1567

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title = "Extension of life-span with superoxide dismutase/catalase mimetics",

abstract = "We tested the theory that reactive oxygen species cause aging. We augmented the natural antioxidant systems of Caenorhabditis elegans with small synthetic superoxide dismutase/catalase mimetics. Treatment of wild-type worms increased their mean life-span by a mean of 44 percent, and treatment of prematurely aging worms resulted in normalization of their life-span (a 67 percent increase). It appears that oxidative stress is a major determinant of life-span and that it can be counteracted by pharmacological intervention.",

author = "S. Melov and J. Ravenscroft and S. Malik and Gill, {M. S.} and Walker, {D. W.} and Clayton, {P. E.} and Wallace, {D. C.} and B. Malfroy and Doctrow, {S. R.} and Lithgow, {G. J.}",

year = "2000",

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doi = "10.1126/science.289.5484.1567",

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TY - JOUR

T1 - Extension of life-span with superoxide dismutase/catalase mimetics

AU - Melov, S.

AU - Ravenscroft, J.

AU - Malik, S.

AU - Gill, M. S.

AU - Walker, D. W.

AU - Clayton, P. E.

AU - Wallace, D. C.

AU - Malfroy, B.

AU - Doctrow, S. R.

AU - Lithgow, G. J.

PY - 2000/9/1

Y1 - 2000/9/1

N2 - We tested the theory that reactive oxygen species cause aging. We augmented the natural antioxidant systems of Caenorhabditis elegans with small synthetic superoxide dismutase/catalase mimetics. Treatment of wild-type worms increased their mean life-span by a mean of 44 percent, and treatment of prematurely aging worms resulted in normalization of their life-span (a 67 percent increase). It appears that oxidative stress is a major determinant of life-span and that it can be counteracted by pharmacological intervention.

AB - We tested the theory that reactive oxygen species cause aging. We augmented the natural antioxidant systems of Caenorhabditis elegans with small synthetic superoxide dismutase/catalase mimetics. Treatment of wild-type worms increased their mean life-span by a mean of 44 percent, and treatment of prematurely aging worms resulted in normalization of their life-span (a 67 percent increase). It appears that oxidative stress is a major determinant of life-span and that it can be counteracted by pharmacological intervention.

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AN - SCOPUS:0034284973

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VL - 289

SP - 1567

EP - 1569

JO - Science

JF - Science

IS - 5484

ER -

Extension of life-span with superoxide dismutase/catalase mimetics

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