Extending the window for thrombolysis for treatment of acute ischaemic stroke during pregnancy: a review

E. Dinehart; C. Leon Guerrero; A. Pham; S. Chandra; S. M. Petersen; S. Bathgate; H. Ahmadzia

doi:10.1111/1471-0528.16495

Extending the window for thrombolysis for treatment of acute ischaemic stroke during pregnancy: a review

E. Dinehart, C. Leon Guerrero, A. Pham, S. Chandra, S. M. Petersen, S. Bathgate, H. Ahmadzia

Research output: Contribution to journal › Review article › peer-review

6 Scopus citations

Abstract

Historically, safety of intravenous recombinant tissue plasminogen activator (IV rt-PA) for the treatment of acute ischaemic stroke (AIS) is limited to use within 4.5 hours from symptom onset. Recent studies suggest the treatment window may be extended when patients have salvageable brain tissue on advanced neuroimaging. This paper describes a novel use of IV rt-PA for treatment of AIS in a pregnant patient within an extended-time window (>4.5 hours, and <9 hours) based on advanced neuroimaging with a favourable outcome. Tweetable abstract: Novel use of IV rt-PA for treatment of AIS in pregnancy within an extended-time window based on advanced imaging with a favourable outcome.

Original language	English (US)
Pages (from-to)	516-520
Number of pages	5
Journal	BJOG: An International Journal of Obstetrics and Gynaecology
Volume	128
Issue number	3
DOIs	https://doi.org/10.1111/1471-0528.16495
State	Published - Feb 2021
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2020 John Wiley & Sons Ltd.

Keywords

Acute ischaemic stroke
extended window
pregnancy
rt-PA
thrombolysis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/1471-0528.16495

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abstract = "Historically, safety of intravenous recombinant tissue plasminogen activator (IV rt-PA) for the treatment of acute ischaemic stroke (AIS) is limited to use within 4.5 hours from symptom onset. Recent studies suggest the treatment window may be extended when patients have salvageable brain tissue on advanced neuroimaging. This paper describes a novel use of IV rt-PA for treatment of AIS in a pregnant patient within an extended-time window (>4.5 hours, and <9 hours) based on advanced neuroimaging with a favourable outcome. Tweetable abstract: Novel use of IV rt-PA for treatment of AIS in pregnancy within an extended-time window based on advanced imaging with a favourable outcome.",

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AU - Leon Guerrero, C.

AU - Pham, A.

AU - Chandra, S.

AU - Petersen, S. M.

AU - Bathgate, S.

AU - Ahmadzia, H.

PY - 2021/2

Y1 - 2021/2

N2 - Historically, safety of intravenous recombinant tissue plasminogen activator (IV rt-PA) for the treatment of acute ischaemic stroke (AIS) is limited to use within 4.5 hours from symptom onset. Recent studies suggest the treatment window may be extended when patients have salvageable brain tissue on advanced neuroimaging. This paper describes a novel use of IV rt-PA for treatment of AIS in a pregnant patient within an extended-time window (>4.5 hours, and <9 hours) based on advanced neuroimaging with a favourable outcome. Tweetable abstract: Novel use of IV rt-PA for treatment of AIS in pregnancy within an extended-time window based on advanced imaging with a favourable outcome.

AB - Historically, safety of intravenous recombinant tissue plasminogen activator (IV rt-PA) for the treatment of acute ischaemic stroke (AIS) is limited to use within 4.5 hours from symptom onset. Recent studies suggest the treatment window may be extended when patients have salvageable brain tissue on advanced neuroimaging. This paper describes a novel use of IV rt-PA for treatment of AIS in a pregnant patient within an extended-time window (>4.5 hours, and <9 hours) based on advanced neuroimaging with a favourable outcome. Tweetable abstract: Novel use of IV rt-PA for treatment of AIS in pregnancy within an extended-time window based on advanced imaging with a favourable outcome.

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Extending the window for thrombolysis for treatment of acute ischaemic stroke during pregnancy: a review

Abstract

Bibliographical note

Keywords

UN SDGs

Publisher link

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