TY - JOUR
T1 - Extending Cord Blood Transplant to Adults
T2 - Dealing With Problems and Results Overall
AU - Brunstein, Claudio G.
AU - Laughlin, Mary J.
PY - 2010/1
Y1 - 2010/1
N2 - The development of newer strategies to overcome, in particular, the cell dose limitation, has increased the availability of umbilical cord blood (UCB) as a source of hematopoietic stem cells (HSC) for transplantation of adults. Among these strategies is the development of the double UCB, ex vivo, and reduced-intensity transplantation platforms. Several ongoing registry-based and single-institution and multicenter clinical trials are investigating ways to make UCB transplantation safer and to improve the outcomes of adults after UCB transplantation. We review the background data and promising newer strategies that will further expand the utilization of UCB for the treatment of adults.
AB - The development of newer strategies to overcome, in particular, the cell dose limitation, has increased the availability of umbilical cord blood (UCB) as a source of hematopoietic stem cells (HSC) for transplantation of adults. Among these strategies is the development of the double UCB, ex vivo, and reduced-intensity transplantation platforms. Several ongoing registry-based and single-institution and multicenter clinical trials are investigating ways to make UCB transplantation safer and to improve the outcomes of adults after UCB transplantation. We review the background data and promising newer strategies that will further expand the utilization of UCB for the treatment of adults.
UR - http://www.scopus.com/inward/record.url?scp=72449158056&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=72449158056&partnerID=8YFLogxK
U2 - 10.1053/j.seminhematol.2009.10.010
DO - 10.1053/j.seminhematol.2009.10.010
M3 - Article
C2 - 20109616
AN - SCOPUS:72449158056
SN - 0037-1963
VL - 47
SP - 86
EP - 96
JO - Seminars in Hematology
JF - Seminars in Hematology
IS - 1
ER -