Extended virulence genotypes and phylogenetic background of Escherichia coli isolates from patients with cystitis, pyelonephritis, or prostatitis

James R. Johnson, Michael A. Kuskowski, Abby Gajewski, Sara Soto, Juan Pablo Horcajada, M. Teresa Jimenez De Anta, Jordi Vila

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114 Scopus citations

Abstract

Molecular analysis of 63 Escherichia coli urine isolates showed that pyelonephritis (n = 23) and prostatitis (n = 17) isolates exhibited more virulence factors (VFs) among the 35 sought than did cystitis isolates (n = 23). Several nontraditional VFs-including bmaE (M fimbriae), gafD (G fimbriae), fyuA (yersiniabactin receptor), ireA and iroN (novel siderophore receptors), cvaC (colicin [microcin] V), traT (serum-resistance associated), ibeA (invasion of brain endothelium), ompT (outer membrane protease T), and malX (pathogenicity island marker)-either differentiated significantly between syndromes (despite small numbers of isolates and possible multiple-comparison artifacts) or were broadly prevalent. Thus, interventions that target conserved uro-VFs may be possible, despite the likely existence of syndrome-specific pathogenetic mechanisms and/or host defense systems.

Original languageEnglish (US)
Pages (from-to)46-50
Number of pages5
JournalJournal of Infectious Diseases
Volume191
Issue number1
DOIs
StatePublished - Jan 1 2005

Bibliographical note

Funding Information:
Financial support: Office of Research and Development, Medical Research Service, Department of Veterans Affairs, and National Research Initiative Competitive Grants Program, US Department of Agriculture (grant 00-35212-9408 to J.R.J.); Ministry of Health, Spain (grant FIS 02/0327 to J.V.); Departament d’Universitats, Recerca I Societat de la Informació de la Generalitat de Catalunya, Spain (grant 2002 SGR00121 to J.V.). a Current affiliation: Aerotek Scientific, Arden Hills, Minnesota.

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