Expression of Tissue Factor in Experimental Bovine Pneumonic Pasteurellosis and Endotoxemia

Javed Rashid, Douglas J. Weiss, Michael P Murtaugh, Ronald R Bach

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Tissue factor (TF), a cell surface-associated cofactor and activator of coagulation factor VII, has been implicated in the local and systemic activation of coagulation associated with sepsis. This study describes the pattern of TF expression in experimental bovine pneumonic pasteurellosis and endotoxemia. Immunohistochemical techniques were used to localize TF antigen in tissue sections. Tissue factor expression was not observed in tissues from control animals. In response to Pasteurella haemolytica challenge, TF was expressed within alveolar walls, by mononuclear inflammatory cells within alveoli, and in walls of arteries, arterioles, bronchi, and bronchioles. Tissue factor was not detected in unaffected lung, liver, spleen, lymph node or kidney tissue. Administration of Escherichia coli endotoxin intravenously resulted in tissue factor expression in lung, spleen, and lymph node tissue. Results of this study indicate that TF is expressed locally at sites of inflammation and systemicalty in endotoxemia. Therefore, TF may be involved in coagulation events associated with pneumonic pasteurellosis.

Original languageEnglish (US)
Pages (from-to)198-202
Number of pages5
JournalVeterinary Clinical Pathology
Volume26
Issue number4
DOIs
StatePublished - Jan 1 1997

Keywords

  • Coagulation
  • Endotoxemia
  • Inflammation
  • Pneumonic pasteurellosis
  • Tissue factor

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