Expression of TAK1, a mediator of TGF-β and BMP signaling, during mouse embryonic development

Joy L. Jadrich, Michael B. O'Connor, Electra Coucouvanis

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


TGF-β activated kinase 1 (TAK1) is a MAP kinase kinase kinase (MAPKKK) that has been shown to function downstream of BMPs and TGF-β (J. Biol. Chem. 275 (2000) 17647; EMBO J. 17 (1998) 1019; Science 270 (1995) 2008), as well as in the interleukin-1 (IL-1) signaling pathway (J. Biol. Chem. 276 (2001) 3508; Nature 398 (1999) 252). Using immunohistochemistry (IHC), we demonstrate that TAK1 is expressed ubiquitously during early development. At mid-gestation, TAK1 expression becomes more restricted, with high levels seen specifically during development of diverse organs and tissues including the nervous system, testis, kidney, liver and gut. Additionally, TAK1 expression is seen in the developing lung and pancreas. Our results suggest that TAK1 may play multiple roles in mouse development.

Original languageEnglish (US)
Pages (from-to)131-134
Number of pages4
JournalGene Expression Patterns
Issue number2
StatePublished - May 2003

Bibliographical note

Funding Information:
We thank Jim Baldrica for technical assistance. J.J. is supported by a Developmental Biology Training Grant (NIH#2T32-HD07480-06). M.B.O. is an Associate Investigator of the Howard Hughes Medical Institute.

Copyright 2008 Elsevier B.V., All rights reserved.


  • Gut
  • Immunohistochemistry
  • Kidney
  • Liver
  • Lung
  • Mouse embryo
  • Nervous system
  • Pancreas
  • TAK1
  • Testis


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