Expression of TAK1, a mediator of TGF-β and BMP signaling, during mouse embryonic development

Joy L. Jadrich; Michael B. O'Connor; Electra Coucouvanis

doi:10.1016/S1567-133X(03)00012-7

Expression of TAK1, a mediator of TGF-β and BMP signaling, during mouse embryonic development

Joy L. Jadrich, Michael B. O'Connor, Electra Coucouvanis

Genetics, Cell Biology and Development (CBS)

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

TGF-β activated kinase 1 (TAK1) is a MAP kinase kinase kinase (MAPKKK) that has been shown to function downstream of BMPs and TGF-β (J. Biol. Chem. 275 (2000) 17647; EMBO J. 17 (1998) 1019; Science 270 (1995) 2008), as well as in the interleukin-1 (IL-1) signaling pathway (J. Biol. Chem. 276 (2001) 3508; Nature 398 (1999) 252). Using immunohistochemistry (IHC), we demonstrate that TAK1 is expressed ubiquitously during early development. At mid-gestation, TAK1 expression becomes more restricted, with high levels seen specifically during development of diverse organs and tissues including the nervous system, testis, kidney, liver and gut. Additionally, TAK1 expression is seen in the developing lung and pancreas. Our results suggest that TAK1 may play multiple roles in mouse development.

Original language	English (US)
Pages (from-to)	131-134
Number of pages	4
Journal	Gene Expression Patterns
Volume	3
Issue number	2
DOIs	https://doi.org/10.1016/S1567-133X(03)00012-7
State	Published - May 1 2003

Keywords

Gut
Immunohistochemistry
Kidney
Liver
Lung
Mouse embryo
Nervous system
Pancreas
TAK1
Testis

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title = "Expression of TAK1, a mediator of TGF-β and BMP signaling, during mouse embryonic development",

abstract = "TGF-β activated kinase 1 (TAK1) is a MAP kinase kinase kinase (MAPKKK) that has been shown to function downstream of BMPs and TGF-β (J. Biol. Chem. 275 (2000) 17647; EMBO J. 17 (1998) 1019; Science 270 (1995) 2008), as well as in the interleukin-1 (IL-1) signaling pathway (J. Biol. Chem. 276 (2001) 3508; Nature 398 (1999) 252). Using immunohistochemistry (IHC), we demonstrate that TAK1 is expressed ubiquitously during early development. At mid-gestation, TAK1 expression becomes more restricted, with high levels seen specifically during development of diverse organs and tissues including the nervous system, testis, kidney, liver and gut. Additionally, TAK1 expression is seen in the developing lung and pancreas. Our results suggest that TAK1 may play multiple roles in mouse development.",

keywords = "Gut, Immunohistochemistry, Kidney, Liver, Lung, Mouse embryo, Nervous system, Pancreas, TAK1, Testis",

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AU - Jadrich, Joy L.

AU - O'Connor, Michael B.

AU - Coucouvanis, Electra

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N2 - TGF-β activated kinase 1 (TAK1) is a MAP kinase kinase kinase (MAPKKK) that has been shown to function downstream of BMPs and TGF-β (J. Biol. Chem. 275 (2000) 17647; EMBO J. 17 (1998) 1019; Science 270 (1995) 2008), as well as in the interleukin-1 (IL-1) signaling pathway (J. Biol. Chem. 276 (2001) 3508; Nature 398 (1999) 252). Using immunohistochemistry (IHC), we demonstrate that TAK1 is expressed ubiquitously during early development. At mid-gestation, TAK1 expression becomes more restricted, with high levels seen specifically during development of diverse organs and tissues including the nervous system, testis, kidney, liver and gut. Additionally, TAK1 expression is seen in the developing lung and pancreas. Our results suggest that TAK1 may play multiple roles in mouse development.

AB - TGF-β activated kinase 1 (TAK1) is a MAP kinase kinase kinase (MAPKKK) that has been shown to function downstream of BMPs and TGF-β (J. Biol. Chem. 275 (2000) 17647; EMBO J. 17 (1998) 1019; Science 270 (1995) 2008), as well as in the interleukin-1 (IL-1) signaling pathway (J. Biol. Chem. 276 (2001) 3508; Nature 398 (1999) 252). Using immunohistochemistry (IHC), we demonstrate that TAK1 is expressed ubiquitously during early development. At mid-gestation, TAK1 expression becomes more restricted, with high levels seen specifically during development of diverse organs and tissues including the nervous system, testis, kidney, liver and gut. Additionally, TAK1 expression is seen in the developing lung and pancreas. Our results suggest that TAK1 may play multiple roles in mouse development.

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KW - Immunohistochemistry

KW - Kidney

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KW - Lung

KW - Mouse embryo

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