TGF-β activated kinase 1 (TAK1) is a MAP kinase kinase kinase (MAPKKK) that has been shown to function downstream of BMPs and TGF-β (J. Biol. Chem. 275 (2000) 17647; EMBO J. 17 (1998) 1019; Science 270 (1995) 2008), as well as in the interleukin-1 (IL-1) signaling pathway (J. Biol. Chem. 276 (2001) 3508; Nature 398 (1999) 252). Using immunohistochemistry (IHC), we demonstrate that TAK1 is expressed ubiquitously during early development. At mid-gestation, TAK1 expression becomes more restricted, with high levels seen specifically during development of diverse organs and tissues including the nervous system, testis, kidney, liver and gut. Additionally, TAK1 expression is seen in the developing lung and pancreas. Our results suggest that TAK1 may play multiple roles in mouse development.
Bibliographical noteFunding Information:
We thank Jim Baldrica for technical assistance. J.J. is supported by a Developmental Biology Training Grant (NIH#2T32-HD07480-06). M.B.O. is an Associate Investigator of the Howard Hughes Medical Institute.
Copyright 2008 Elsevier B.V., All rights reserved.
- Mouse embryo
- Nervous system