Expression of somatostatin receptors in childhood neuroblastoma

C. L. Moertel, J. C. Reubi, B. S. Scheithauer, D. J. Schaid, L. K. Kvols

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Abstract

Somatostatin receptors are expressed on certain neural crest-derived tumors, including pancreatic islet cell and carcinoid tumors, medullary thyroid carcinomas, pheochromocytomas, and paragangliomas. The authors evaluated the expression of high affinity somatostatin receptors in childhood neuroblastoma using autoradiography techniques with the somatostatin analogue 125I-octreotide or 125I-[Leu8, D-Trp22, Tyr25]-SS-28 as the radioligand. Thirty tumors from 30 children with neuroblastoma were analyzed. Twenty-three of 30 tumors that were tested expressed somatostatin receptors. Correlation of somatostatin receptor expression with survival was statistically significant. The survival of those patients whose tumors expressed somatostatin receptors was of longer duration than that of patients whose tumors did not. This was an independent prognostic factor. Somatostatin receptors were expressed more frequently in tumor tissue from patients with lower stages of disease and in those with no evidence of N-myc amplification. Tumoral somatostatin receptors are expressed in a subgroup of patients with childhood neuroblastoma. Survival analysis in this group of patients indicates that somatostatin receptor expression is a favorable prognostic factor. This finding may have important implications for the therapy of children with this malignancy.

Original languageEnglish (US)
Pages (from-to)752-756
Number of pages5
JournalAmerican journal of clinical pathology
Volume102
Issue number6
StatePublished - Dec 1 1994

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Keywords

  • Childhood malignancy
  • N- myc
  • Neuroblastoma
  • Neuroendocrine tumors
  • Octreotide
  • Somatostatin receptor

Cite this

Moertel, C. L., Reubi, J. C., Scheithauer, B. S., Schaid, D. J., & Kvols, L. K. (1994). Expression of somatostatin receptors in childhood neuroblastoma. American journal of clinical pathology, 102(6), 752-756.