Expression of intercellular adhesion molecule-1 in rat inner ear due to bacterial otitis media

Michihiko Sone, Daniel M. Canafax, Henry Q. Russlie, Michael M. Paparella

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Expressions of anti-Streptococcus pneumoniae antibody and anti- intercellular adhesion molecule-1 (ICAM-1) antibody in the inner ear were studied immunohistochemically in rats following inoculation of S pneumoniae type 6A into the middle ear cavity. Positive staining with anti-S pneumoniae antibody was detected in the marginal cells of the stria vascularis of rats sacrificed 3 days after S pneumoniae inoculation, but almost no staining was detected in those sacrificed at 14 days. Strong ICAM-1 expression was detected in the basal cell layer of the stria vascularis of rats sacrificed 3 days after inoculation, but the intensity of the staining had decreased by 14 days. These results suggest that the stria vascularis may be a site of the inner ear damage that follows bacterial inoculation into the middle ear cavity. The up-regulated expression of ICAM-1 in the basal cell layer may represent a reaction of the inner ear to the bacterial otitis media.

Original languageEnglish (US)
Pages (from-to)648-652
Number of pages5
JournalAnnals of Otology, Rhinology and Laryngology
Volume108
Issue number7 I
DOIs
StatePublished - Jan 1 1999

Keywords

  • Adhesion molecule
  • Otitis media
  • Rat
  • Streptococcus pneumoniae
  • Stria vascularis

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