Expression of HER-2 and nuclear localization of HER-3 protein in canine mammary tumors: Histopathological and immunohistochemical study

J. H. Kim; K. S. Im; N. H. Kim; J. Y. Yhee; W. G. Nho; J. H. Sur

doi:10.1016/j.tvjl.2010.08.012

Expression of HER-2 and nuclear localization of HER-3 protein in canine mammary tumors: Histopathological and immunohistochemical study

J. H. Kim, K. S. Im, N. H. Kim, J. Y. Yhee, W. G. Nho, J. H. Sur

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

HER-2 and HER-3 are transmembrane receptor proteins that are considered to be important but poorly understood biomarkers in canine tumors. In this study, the expression and the localization of HER-2 and HER-3 were evaluated immunohistochemically in canine mammary tumors (n= 64; 12 benign, 52 malignant).HER-2 overexpression was identified in 2/12 (16.7%) benign and in 18/51 (35.3%) malignant cases. HER-3 was expressed in a non-nuclear localization in 11/12 (91.7%) benign and 18/52 (34.6%) malignant tumors. In contrast, HER-3 was expressed in the nucleus of neoplastic cells in 0/12 (0%) benign and 22/52 (42.3%) malignant tumors. Nuclear HER-3 expression was higher in neoplastic epithelial cells compared to myoepithelial cells, and positively correlated with high histological grade and lymphatic vessel invasion. These results suggest that nuclear HER-3 expression is significantly associated with tumor progression and metastasis and may serve as a useful prognostic biomarker in canine malignant mammary tumors.

Original language	English (US)
Pages (from-to)	318-322
Number of pages	5
Journal	Veterinary Journal
Volume	189
Issue number	3
DOIs	https://doi.org/10.1016/j.tvjl.2010.08.012
State	Published - Sep 2011
Externally published	Yes

Bibliographical note

Funding Information:
We would like to thank Ms. R.H. Jang for her excellent technical assistance and private animal clinics for providing canine mammary samples. This study was supported by a Grant from the Konkuk University Research Foundation 2010.

Copyright:
Copyright 2012 Elsevier B.V., All rights reserved.

Keywords

Dog
HER-3
Mammary tumors
Nuclear protein
Prognostic factor

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.tvjl.2010.08.012

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title = "Expression of HER-2 and nuclear localization of HER-3 protein in canine mammary tumors: Histopathological and immunohistochemical study",

abstract = "HER-2 and HER-3 are transmembrane receptor proteins that are considered to be important but poorly understood biomarkers in canine tumors. In this study, the expression and the localization of HER-2 and HER-3 were evaluated immunohistochemically in canine mammary tumors (n= 64; 12 benign, 52 malignant).HER-2 overexpression was identified in 2/12 (16.7%) benign and in 18/51 (35.3%) malignant cases. HER-3 was expressed in a non-nuclear localization in 11/12 (91.7%) benign and 18/52 (34.6%) malignant tumors. In contrast, HER-3 was expressed in the nucleus of neoplastic cells in 0/12 (0%) benign and 22/52 (42.3%) malignant tumors. Nuclear HER-3 expression was higher in neoplastic epithelial cells compared to myoepithelial cells, and positively correlated with high histological grade and lymphatic vessel invasion. These results suggest that nuclear HER-3 expression is significantly associated with tumor progression and metastasis and may serve as a useful prognostic biomarker in canine malignant mammary tumors.",

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author = "Kim, {J. H.} and Im, {K. S.} and Kim, {N. H.} and Yhee, {J. Y.} and Nho, {W. G.} and Sur, {J. H.}",

note = "Funding Information: We would like to thank Ms. R.H. Jang for her excellent technical assistance and private animal clinics for providing canine mammary samples. This study was supported by a Grant from the Konkuk University Research Foundation 2010. Copyright: Copyright 2012 Elsevier B.V., All rights reserved.",

year = "2011",

month = sep,

doi = "10.1016/j.tvjl.2010.08.012",

language = "English (US)",

volume = "189",

pages = "318--322",

journal = "Veterinary Journal",

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AU - Kim, J. H.

AU - Im, K. S.

AU - Kim, N. H.

AU - Yhee, J. Y.

AU - Nho, W. G.

AU - Sur, J. H.

N1 - Funding Information: We would like to thank Ms. R.H. Jang for her excellent technical assistance and private animal clinics for providing canine mammary samples. This study was supported by a Grant from the Konkuk University Research Foundation 2010. Copyright: Copyright 2012 Elsevier B.V., All rights reserved.

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N2 - HER-2 and HER-3 are transmembrane receptor proteins that are considered to be important but poorly understood biomarkers in canine tumors. In this study, the expression and the localization of HER-2 and HER-3 were evaluated immunohistochemically in canine mammary tumors (n= 64; 12 benign, 52 malignant).HER-2 overexpression was identified in 2/12 (16.7%) benign and in 18/51 (35.3%) malignant cases. HER-3 was expressed in a non-nuclear localization in 11/12 (91.7%) benign and 18/52 (34.6%) malignant tumors. In contrast, HER-3 was expressed in the nucleus of neoplastic cells in 0/12 (0%) benign and 22/52 (42.3%) malignant tumors. Nuclear HER-3 expression was higher in neoplastic epithelial cells compared to myoepithelial cells, and positively correlated with high histological grade and lymphatic vessel invasion. These results suggest that nuclear HER-3 expression is significantly associated with tumor progression and metastasis and may serve as a useful prognostic biomarker in canine malignant mammary tumors.

AB - HER-2 and HER-3 are transmembrane receptor proteins that are considered to be important but poorly understood biomarkers in canine tumors. In this study, the expression and the localization of HER-2 and HER-3 were evaluated immunohistochemically in canine mammary tumors (n= 64; 12 benign, 52 malignant).HER-2 overexpression was identified in 2/12 (16.7%) benign and in 18/51 (35.3%) malignant cases. HER-3 was expressed in a non-nuclear localization in 11/12 (91.7%) benign and 18/52 (34.6%) malignant tumors. In contrast, HER-3 was expressed in the nucleus of neoplastic cells in 0/12 (0%) benign and 22/52 (42.3%) malignant tumors. Nuclear HER-3 expression was higher in neoplastic epithelial cells compared to myoepithelial cells, and positively correlated with high histological grade and lymphatic vessel invasion. These results suggest that nuclear HER-3 expression is significantly associated with tumor progression and metastasis and may serve as a useful prognostic biomarker in canine malignant mammary tumors.

KW - Dog

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KW - Mammary tumors

KW - Nuclear protein

KW - Prognostic factor

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Expression of HER-2 and nuclear localization of HER-3 protein in canine mammary tumors: Histopathological and immunohistochemical study

Abstract

Bibliographical note

Keywords

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