Expression of Fgf19 in the developing chick eye

Javier Francisco-Morcillo; Hortensia Sánchez-Calderón; Yasuhiko Kawakami; Juan Carlos Izpisúa Belmonte; Matías Hidalgo-Sánchez; Gervasio Martín-Partido

doi:10.1016/j.devbrainres.2004.12.011

Expression of Fgf19 in the developing chick eye

Javier Francisco-Morcillo, Hortensia Sánchez-Calderón, Yasuhiko Kawakami, Juan Carlos Izpisúa Belmonte, Matías Hidalgo-Sánchez, Gervasio Martín-Partido

Genetics, Cell Biology and Development (TMED)

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Fibroblast growth factor 19 (FGF19) is a new member of the FGF family of growth factors. Here, we describe the localization of Fgf19 mRNA in the developing chick retina and lens in stages from the Hamburger and Hamilton stage 15 (HH15) to postnatal day 30 (P30). Fgf19 was expressed in a transient manner in postmitotic neuroblasts during the migration from the ventricular surface to their final location. Moreover, from HH31 (embryonic day 7, E7) on, a subset of lined up Fgf19 expressing cells was distributed in the outer region of the presumptive INL. These cells were Pax6 immunoreactive horizontal cells. During the last third of embryogenesis, Fgf19 expression in the retina was progressively down-regulated and was not detected at P30. Also, it was transiently expressed in the equatorial region of the lens.

Original language	English (US)
Pages (from-to)	104-109
Number of pages	6
Journal	Developmental Brain Research
Volume	156
Issue number	1
DOIs	https://doi.org/10.1016/j.devbrainres.2004.12.011
State	Published - Apr 21 2005

Bibliographical note

Funding Information:
Thanks are due to María Salud Holguín-Arévalo and Miguel Ángel Ortiz-Ortiz for providing expert technical assistance. We are grateful to Joaquín Rodríguez-León and William Wood for insightful comments that helped contribute to the final form of the manuscript. During this work, JFM was the recipient of a fellowship from the Consejería de Educación, Ciencia y Tecnología, Junta de Extremadura and Fondo Social Europeo. HSC was the recipient of a studentship from the Spanish Ministry of Education and Culture. This work was supported by the Spanish Ministry of Science and Technology (PB97-0364) and the Junta de Extremadura (IPR98C028 and 2PR02A077). YK and JCIB are supported by grants from The G. Harold and Leila Y. Mathers Foundation and the NIH.

Keywords

Chick embryo
Fgf19
Gradients of differentiation
Neurogenesis
Retinal development
Retinal neuroblasts

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10.1016/j.devbrainres.2004.12.011

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title = "Expression of Fgf19 in the developing chick eye",

abstract = "Fibroblast growth factor 19 (FGF19) is a new member of the FGF family of growth factors. Here, we describe the localization of Fgf19 mRNA in the developing chick retina and lens in stages from the Hamburger and Hamilton stage 15 (HH15) to postnatal day 30 (P30). Fgf19 was expressed in a transient manner in postmitotic neuroblasts during the migration from the ventricular surface to their final location. Moreover, from HH31 (embryonic day 7, E7) on, a subset of lined up Fgf19 expressing cells was distributed in the outer region of the presumptive INL. These cells were Pax6 immunoreactive horizontal cells. During the last third of embryogenesis, Fgf19 expression in the retina was progressively down-regulated and was not detected at P30. Also, it was transiently expressed in the equatorial region of the lens.",

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author = "Javier Francisco-Morcillo and Hortensia S{\'a}nchez-Calder{\'o}n and Yasuhiko Kawakami and Belmonte, {Juan Carlos Izpis{\'u}a} and Mat{\'i}as Hidalgo-S{\'a}nchez and Gervasio Mart{\'i}n-Partido",

note = "Funding Information: Thanks are due to Mar{\'i}a Salud Holgu{\'i}n-Ar{\'e}valo and Miguel {\'A}ngel Ortiz-Ortiz for providing expert technical assistance. We are grateful to Joaqu{\'i}n Rodr{\'i}guez-Le{\'o}n and William Wood for insightful comments that helped contribute to the final form of the manuscript. During this work, JFM was the recipient of a fellowship from the Consejer{\'i}a de Educaci{\'o}n, Ciencia y Tecnolog{\'i}a, Junta de Extremadura and Fondo Social Europeo. HSC was the recipient of a studentship from the Spanish Ministry of Education and Culture. This work was supported by the Spanish Ministry of Science and Technology (PB97-0364) and the Junta de Extremadura (IPR98C028 and 2PR02A077). YK and JCIB are supported by grants from The G. Harold and Leila Y. Mathers Foundation and the NIH.",

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AU - Sánchez-Calderón, Hortensia

AU - Kawakami, Yasuhiko

AU - Belmonte, Juan Carlos Izpisúa

AU - Hidalgo-Sánchez, Matías

AU - Martín-Partido, Gervasio

N1 - Funding Information: Thanks are due to María Salud Holguín-Arévalo and Miguel Ángel Ortiz-Ortiz for providing expert technical assistance. We are grateful to Joaquín Rodríguez-León and William Wood for insightful comments that helped contribute to the final form of the manuscript. During this work, JFM was the recipient of a fellowship from the Consejería de Educación, Ciencia y Tecnología, Junta de Extremadura and Fondo Social Europeo. HSC was the recipient of a studentship from the Spanish Ministry of Education and Culture. This work was supported by the Spanish Ministry of Science and Technology (PB97-0364) and the Junta de Extremadura (IPR98C028 and 2PR02A077). YK and JCIB are supported by grants from The G. Harold and Leila Y. Mathers Foundation and the NIH.

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N2 - Fibroblast growth factor 19 (FGF19) is a new member of the FGF family of growth factors. Here, we describe the localization of Fgf19 mRNA in the developing chick retina and lens in stages from the Hamburger and Hamilton stage 15 (HH15) to postnatal day 30 (P30). Fgf19 was expressed in a transient manner in postmitotic neuroblasts during the migration from the ventricular surface to their final location. Moreover, from HH31 (embryonic day 7, E7) on, a subset of lined up Fgf19 expressing cells was distributed in the outer region of the presumptive INL. These cells were Pax6 immunoreactive horizontal cells. During the last third of embryogenesis, Fgf19 expression in the retina was progressively down-regulated and was not detected at P30. Also, it was transiently expressed in the equatorial region of the lens.

AB - Fibroblast growth factor 19 (FGF19) is a new member of the FGF family of growth factors. Here, we describe the localization of Fgf19 mRNA in the developing chick retina and lens in stages from the Hamburger and Hamilton stage 15 (HH15) to postnatal day 30 (P30). Fgf19 was expressed in a transient manner in postmitotic neuroblasts during the migration from the ventricular surface to their final location. Moreover, from HH31 (embryonic day 7, E7) on, a subset of lined up Fgf19 expressing cells was distributed in the outer region of the presumptive INL. These cells were Pax6 immunoreactive horizontal cells. During the last third of embryogenesis, Fgf19 expression in the retina was progressively down-regulated and was not detected at P30. Also, it was transiently expressed in the equatorial region of the lens.

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Expression of Fgf19 in the developing chick eye

Abstract

Bibliographical note

Keywords

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