Expression of endogenous muscarinic acetylcholine receptors in Chinese hamster ovary cells

Zhen Wang Shou Zhen Wang, Zu Zhu Sheng Zu Zhu, Esam E. El-Fakahany

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Chinese hamster ovary (CHO) cells are commonly used for expression of the genes of cloned neurotransmitter receptors to study their pharmacology and coupling to signal transduction pathways. It is usually assumed that host cells do not endogenously express the specific receptor under consideration. We demonstrate in this report that CHO cells contain endogenous functional muscarinic acetylcholine receptors which, in some circumstances, might complicate interpretation of data related to the properties of exogenously expressed receptors.

Original languageEnglish (US)
Pages (from-to)R1-R2
JournalEuropean Journal of Pharmacology - Molecular Pharmacology Section
Volume291
Issue number2
StatePublished - Oct 15 1995

Keywords

  • Chinese hamster ovary (CHO) cell
  • Muscarinic acetylcholine receptor
  • Nitric oxide (NO)

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