Expression of cytokine receptors and markers of differentiation in human papillomavirus-infected cervical tissues

Ronald C. McGlennen; Ronald S. Ostrow; Linda F Carson; Michael S. Stanley; Anthony J. Faras

doi:10.1016/0002-9378(91)90312-F

Expression of cytokine receptors and markers of differentiation in human papillomavirus-infected cervical tissues

Ronald C. McGlennen, Ronald S. Ostrow, Linda F Carson, Michael S. Stanley, Anthony J. Faras

Obstetrics, Gynecology and Women's Health - Oncology

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Human papillomavirus infection of the uterine cervix is associated with a spectrum of benign, premalignant, and malignant epithelial lesions, a process that appears to require the coordinated effects of secondary cellular and environmental events. We have used flow cytometry and immunohistochemistry to examine the expression of the cellular markers for proliferation (interleukin-1, epidermal growth factor receptor, and transferrin receptor) and the markers of cellular differentiation (filaggrin and low-molecular-weight cytokeratin) in normal and human papillomavirus-infected human cervical tissues representing the natural range of human papillomavirus-induced disease. The results were correlated with the histologic grade of disease, human papillomavirus type, cellular deoxyribonucleic acid content, and cell cycle status. Interleukin-1 and transferrin receptor were slightly increased in high-grade dysplasias and in squamous cell carcinomas. Filaggrin expression was found to be inversely related and cytokeratin and epidermal growth factor receptor expression directly related to the degree of neoplasia. These findings indicate that cytokeratin and epidermal growth factor receptor are useful markers of cell proliferation in human papillomavirus-infected tissues and that their expression may directly increase as a result of infection.

Original language	English (US)
Pages (from-to)	696-705
Number of pages	10
Journal	American journal of obstetrics and gynecology
Volume	165
Issue number	3
DOIs	https://doi.org/10.1016/0002-9378(91)90312-F
State	Published - Sep 1991

Bibliographical note

Funding Information:
From the Departments of Laboratory Medicine and Pathology," Microbiology,' and Obstetrics and Gynecologyd and the Institute of Human Genetics/ University of Minnesota Medical School. Supported by a grant from the National Institutes of Health (CA25462) and the Leukemia Research Fund. Received for publication October 16, 1990; revised February 13, 1991; accepted March 1, 1991. Reprint requests: Ronald S. Ostrow, PhD, Box 206 UMHC, Institute of Human Genetics, University of Minnesota, Harvard St at East R iver Road, Minneapolis, MN 55455.

Keywords

Human papillomavirus deoxyribonucleic acid
cellular differentiation
flow cytometry
growth factors

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0002-9378(91)90312-F

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title = "Expression of cytokine receptors and markers of differentiation in human papillomavirus-infected cervical tissues",

abstract = "Human papillomavirus infection of the uterine cervix is associated with a spectrum of benign, premalignant, and malignant epithelial lesions, a process that appears to require the coordinated effects of secondary cellular and environmental events. We have used flow cytometry and immunohistochemistry to examine the expression of the cellular markers for proliferation (interleukin-1, epidermal growth factor receptor, and transferrin receptor) and the markers of cellular differentiation (filaggrin and low-molecular-weight cytokeratin) in normal and human papillomavirus-infected human cervical tissues representing the natural range of human papillomavirus-induced disease. The results were correlated with the histologic grade of disease, human papillomavirus type, cellular deoxyribonucleic acid content, and cell cycle status. Interleukin-1 and transferrin receptor were slightly increased in high-grade dysplasias and in squamous cell carcinomas. Filaggrin expression was found to be inversely related and cytokeratin and epidermal growth factor receptor expression directly related to the degree of neoplasia. These findings indicate that cytokeratin and epidermal growth factor receptor are useful markers of cell proliferation in human papillomavirus-infected tissues and that their expression may directly increase as a result of infection.",

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author = "McGlennen, {Ronald C.} and Ostrow, {Ronald S.} and Carson, {Linda F} and Stanley, {Michael S.} and Faras, {Anthony J.}",

note = "Funding Information: From the Departments of Laboratory Medicine and Pathology,{"} Microbiology,' and Obstetrics and Gynecologyd and the Institute of Human Genetics/ University of Minnesota Medical School. Supported by a grant from the National Institutes of Health (CA25462) and the Leukemia Research Fund. Received for publication October 16, 1990; revised February 13, 1991; accepted March 1, 1991. Reprint requests: Ronald S. Ostrow, PhD, Box 206 UMHC, Institute of Human Genetics, University of Minnesota, Harvard St at East R iver Road, Minneapolis, MN 55455.",

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AB - Human papillomavirus infection of the uterine cervix is associated with a spectrum of benign, premalignant, and malignant epithelial lesions, a process that appears to require the coordinated effects of secondary cellular and environmental events. We have used flow cytometry and immunohistochemistry to examine the expression of the cellular markers for proliferation (interleukin-1, epidermal growth factor receptor, and transferrin receptor) and the markers of cellular differentiation (filaggrin and low-molecular-weight cytokeratin) in normal and human papillomavirus-infected human cervical tissues representing the natural range of human papillomavirus-induced disease. The results were correlated with the histologic grade of disease, human papillomavirus type, cellular deoxyribonucleic acid content, and cell cycle status. Interleukin-1 and transferrin receptor were slightly increased in high-grade dysplasias and in squamous cell carcinomas. Filaggrin expression was found to be inversely related and cytokeratin and epidermal growth factor receptor expression directly related to the degree of neoplasia. These findings indicate that cytokeratin and epidermal growth factor receptor are useful markers of cell proliferation in human papillomavirus-infected tissues and that their expression may directly increase as a result of infection.

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Expression of cytokine receptors and markers of differentiation in human papillomavirus-infected cervical tissues

Abstract

Bibliographical note

Keywords

UN SDGs

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