Expression of cardiac neural crest and heart genes isolated by modified differential display

Brad J. Martinsen, Nathan J. Groebner, Allison J. Frasier, Jamie L Lohr

Research output: Contribution to journalArticle

8 Scopus citations


The invasion of the cardiac neural crest (CNC) into the outflow tract (OFT) and subsequent outflow tract septation are critical events during vertebrate heart development. We have performed four modified differential display screens in the chick embryo to identify genes that may be involved in CNC, OFT, secondary heart field, and heart development. The screens included differential display of RNA isolated from three different axial segments containing premigratory cranial neural crest cells; of RNA from distal outflow tract, proximal outflow tract, and atrioventricular tissue of embryonic chick hearts; and of RNA isolated from left and right cranial tissues, including the early heart fields. These screens have resulted in the identification of the five cDNA clones presented here, which are expressed in the cardiac neural crest, outflow tract and developing heart in patterns that are unique in heart development.

Original languageEnglish (US)
Pages (from-to)407-411
Number of pages5
JournalGene Expression Patterns
Issue number4
StatePublished - Aug 2003


  • Cardiac chamber specification
  • Cardiac inflow
  • Cardiac neural crest
  • Cardiac valve formation
  • Chick
  • Congenital heart disease
  • Differential display
  • Differential expression
  • Heart development
  • Linear heart tube
  • Neural crest
  • Notochord
  • Outflow tract septation
  • Secondary heart field

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