Expression of and correlational patterns among neuroinflammatory, neuropeptide, and neuroendocrine molecules from cerebrospinal fluid in cerebral palsy

Cory J. Goracke-Postle, Chantel C. Burkitt, Angela Panoskaltsis-Mortari, Michael Ehrhardt, George L. Wilcox, Patrick Graupman, Michael Partington, Frank J. Symons

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The underlying pathogenesis of cerebral palsy (CP) remains poorly understood. The possibility of an early inflammatory response after acute insult is of increasing interest. Patterns of inflammatory and related biomarkers are emerging as potential early diagnostic markers for understanding the etiologic diversity of CP. Their presence has been investigated in plasma and umbilical cord blood but not in cerebrospinal fluid (CSF). Methods: A clinical CP sample was recruited using a single-time point cross-sectional design to collect CSF at point-of-care during a standard-of-care surgical procedure (intrathecal pump implant). Patient demographic and clinical characteristics were sourced from medical chart audit. Results: Significant (p ≤ 0.001) associations were found among neuroinflammatory, neuroendocrine, and nociceptive analytes with association patterns varying by birth status (term, preterm, extremely preterm). When between birth-group correlations were compared directly, there was a significant difference between preterm and extremely preterm birth subgroups for the correlation between tumour necrosis factor alpha (TNFα) and substance P. Conclusion: This investigation shows that CSF can be used to study proteins in CP patients. Differences in inter-correlational patterns among analytes varying by birth status underscores the importance of considering birth status in relation to possible mechanistic differences as indicated by biomarker signatures. Future work should be oriented toward prognostic and predictive validity to continue to parse the heterogeneity of CP’s presentation, pathophysiology, and response to treatment.

Original languageEnglish (US)
Article number384
JournalBMC neurology
Volume21
Issue number1
DOIs
StatePublished - Dec 2021

Bibliographical note

Funding Information:
This study was funded, in part, by Eunice Kennedy Shriver NICHD Grant No. 73126.

Publisher Copyright:
© 2021, The Author(s).

Keywords

  • Biomarkers
  • CSF
  • Cerebral palsy
  • Children
  • Neuroendocrine
  • Neuroinflammation
  • Nociceptive

PubMed: MeSH publication types

  • Journal Article

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