Expression and significance of PTEN in canine mammary gland tumours

Changwei Qiu, Degui Lin, Jinqiu Wang, Lei Wang

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

To explore the expression and clinical importance of the anti-oncogene phosphatase and tensin homologue deleted on chromosome 10 (PTEN) in canine mammary gland tumours, PTEN expression was compared in 50 cases of canine mammary tumour and four examples of normal mammary tissue using real-time quantitative PCR. PTEN expression was similar in benign mammary tumours and normal mammary tissues (P > 0.05), but was lower in malignant tumours than in normal mammary tissues or benign mammary tumours (P < 0.001). PTEN expression was also low in the lymph node metastases of malignant mammary tumours. The expression profile of PTEN in malignant mammary tumours compared to those without lymph node metastasis varied significantly. Low-level PETN expression might play an important role in carcinogenesis and the progression of canine mammary tumours, and PTEN protein detection might be useful in evaluating tumour development and prognosis.

Original languageEnglish (US)
Pages (from-to)383-388
Number of pages6
JournalResearch in veterinary science
Volume85
Issue number2
DOIs
StatePublished - Oct 2008

Bibliographical note

Funding Information:
This study was supported by a research grant from the National Natural Science Foundation of China (30471275). We thank Lei Wang for excellent technical support.

Keywords

  • Canine mammary gland tumour
  • Metastasis
  • PTEN
  • Real-time quantitative PCR

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