Aims: Cannabis use disorders (CUDs) in adolescence are associated with increased risk for later major depressive disorder (MDD). The goal of this study was to examine the "psychosocial failure" explanation for this association: the possibility that psychosocial consequences of CUDs in adolescence account for the increased risk for later MDD. Methods: Participants (n= 1252) were drawn from the community-based sample of the Minnesota Twin Family Study and were assessed at ages 17, 20, and 24. CUDs and MDD were assessed via structured interview. "Psychosocial failure" was defined as educational failure (high school dropout), occupational failure (persistent unemployment), or engagement in crime. Results: Psychosocial failure partially mediated the association between CUDs in adolescence and later MDD. Conclusions: The adverse psychosocial consequences of CUDs in adolescence partially - but not fully - account for the observed association between early CUDs and later MDD.
Bibliographical noteFunding Information:
This study was supported by grants AA09367 from the National Institute on Alcohol Abuse and Alcoholism , and DA022456 , DA05147 and DA016892 from the National Institute on Drug Abuse .
This study was supported by grants AA09367 from the National Institute on Alcohol Abuse and Alcoholism, and DA022456, DA05147 and DA016892 from the National Institute on Drug Abuse. NIAAA and NIDA had no role in the study design, collection, analysis or interpretation of the data, writing the manuscript, or the decision to submit the paper for publication.
- Cannabis abuse
- Cannabis dependence
- Major depression