Expert systems in the control of animal cell culture processes: Potentials, functions, and perspectives

Konstantin B. Konstantinov, Weichang Zhou, Fred Golini, Wei-Shou Hu

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

In recent years, the development of advanced systems for bioprocess monitoring and control has become an area of intensive research. Along with traditional techniques, there are several new approaches which are increasingly being applied to bioprocess operations. Among these, of special note is expert system technology, which provides possibilities for the design of efficient bioprocess control systems with new functional capabilities. This technology has been successfully applied to variety of microbial processes at laboratory and industrial scale. The present paper analyzes the possibility for application of expert systems to animal cell cultures processes whose high complexity is well suited to expert control. The discussion focuses on the organization and the functionality of the intelligent control systems, and covers some practical aspects of their design.

Original languageEnglish (US)
Pages (from-to)233-246
Number of pages14
JournalCytotechnology
Volume14
Issue number3
DOIs
StatePublished - Jan 1 1994

Keywords

  • artificial intelligence
  • bioprocess control
  • bioprocess monitoring
  • expert systems
  • hybridoma cell culture
  • mammalian cell cultures

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