Experimentally induced Mycobacterium avium serotype 8 infection in swine.

C. O. Thoen, D. W. Johnson, E. M. Himes, S. B. Menke, C. C. Muscoplat

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Five of 6 swine experimentally inoculated with Mycobacterium avium serotype 8 had microgranulomas in the cervical or mesenteric lymph nodes at necropsy 92 days later. In vivo tuberculin skin reactivity and in vitro lymphocyte immunostimulation responses were evaluated at 10 and 12 weeks after the pigs were inoculated. Positive responses were obtained on both tests in inoculated pigs, whereas test results in noninoculated pigs and pigs given killed bacterial cells were negative. Mycobacterium avium serotype 8 was isolated at necropsy from the cervical or mesenteric lymph nodes of each of the pigs inoculated with viable microorganisms and from the 2 pigs kept in the pen with inoculated swine. Mycobacteria were not isolated from tissues of the noninoculated swine or those given killed cells.

Original languageEnglish (US)
Pages (from-to)177-181
Number of pages5
JournalAmerican Journal of Veterinary Research
Volume37
Issue number2
StatePublished - Feb 1 1976

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